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Argonaute 1 regulates germ cell division and oocyte determination in Drosophila melanogaster
University of Oxford
We find that Ago1 protein is be enriched in the oocytes and also distributed in the cytoplasm of follicle cells. Using mitotic clonal analysis, we analyze multiple ago1 mutant alleles. Here, we find that the oocyte do not form in many mutant clones and they only have 8 nurse cells. These results indicate that the level of Ago1 affects the number of cystoblast divisions and oocyte determination. |
Immunomodulatory Properties of Adipose-Derived Stem Cells Cultured in Autologous Serum
Latvian Biomedical Research and Study Centre
This study investigated whether adipose-derived stem cells (ADSC), cultivated in the medium containing autologous serum, maintain immunomodulatory properties of MSC. Obtained cells were CD73, CD90 and CD105 positive but CD34 and CD45 negative. ADSC underwent in vitro differentiation into adipocytes, osteoblasts and chondroblasts. Immunomodulatory properties of ADSC were investigated by blast transformation reaction and significant suppression of T lymphocyte proliferation was induced in a dose d |
Development of cell culture system on the basis of adult stem cells for modeling of HBV infection
Latvian Biomedical Research and Study Centre
Efforts to elucidate the mechanisms by which HBV infects hepatocytes and causes liver damage have been hampered by the strict virus host range and a lack of suitable cell culture and animal models of HBV infection/replication. The present study has established and elucidated a novel HBV infection/replication in vitro model system based on adipose-derived stem cells differentiated into human hepatocyte-like cell line. |
Specificity of small molecule inhibitors for deubiquitinating enzymes in living cells assessed by activity-based proteomics
*Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK, #Progenra Inc, Malvern, PA 19355, USA
Small molecular compounds (PR-619 and P22077) was assessed for their abilities to inhibit DUB function in crude extracts and in cells. Activity-based profiling combined with quantitative mass spectrometry revealed the inhibitory capacity of a broad range of DUBs by the PR-619, whereas P22077 showed specificity towards subsets of DUBs including USP7 in cells. Our results demonstrate the usefulness of activity-based quantitative proteomics to monitor inhibition of endogenous DUBs in vivo. |
Mechanism for recognition of polyubiquitin chains
University of Alberta
NMR spectroscopy was used to characterize the binding of RAP80-tUIM to mono Ub and extended tandem polyUb chains. |
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Assistant/Associate Professors
Chinese University of Hong Kong
The newly established School of Biomedical Sciences, Stem Cell and Regeneration theme is actively looking for stem cell biologist over the next 2 years. |
Engineer Technician, Fayetteville, Arizona, USA
SFC-Fluidics
SFC Fluidics is looking to hire a highly motivated, detail-oriented engineer technician.
oral communication skills . Experience with GMP and GLP desired |
Computer Scientists in Genomics
Institute for Molecular Biology
The newly founded Institute for Molecular Biology (IMB) is an Excellence Center for Life Science, funded by the Boehringer Ingelheim Foundation, and located in Mainz, Germany. |
Computational Medicinal Chemistry Post-Doc Position, Siena, Italy
University of Siena
NatSynDrugs Is Seeking Candidates For a Computational Medicinal Chemistry Post-Doc Position |
Mass Spectrometry Scientist (#1753)
Roswell Park Cancer Institute
The Roswell Park Cancer Institute Division of Health Research Inc. is seeking a full-time Mass Spectrometry Scientist to develop and validate analytical assays for cancer drugs and their metabolites in biological matrices such as plasma, urine, cells and tissues using LC-MS, LC-MS/MS, HPLC and/or UPLC. |
Senior Scientific Marketing Writer - Life Sciences
Alto Marketing
For a challenging career using your advanced life science background and writing strengths, please read on. |
Senior Account Manager/Account Director
Alto Marketing
The best career move for a well-connected marketing professional with real leadership ability and drive! |
Senior Scientist, Metabolism
Agios
Agios Pharmaceuticals is seeking a PhD Scientist to join a team that is building and applying a state-of-art approach to investigate the intersection of cancer cell biology and metabolism.
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Automation Engineer, Metabolism, Agios Pharmaceuticals, Cambridge, MA, USA
Agios Pharmaceuticals
With new research showing that cancer cells become addicted to using more nutrients than normal cells to promote their rapid growth, there is an unprecedented opportunity to create a new class of oncology therapeutics that target a fundamental and ubiquitous mechanism in cancer cells. The intersection of these two fields of research - cancer and metabolism- represents an important and novel approach to treating cancer.
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Post-doctoral position at INRA (France)
INRA
An 18-month post-doctoral position is available at INRA Clermont-Ferrand-Theix (France).The position is opened to both French and foreign applicants. |
Protein NMR/Biophysics Research Associate (BS/MS)
Novartis Institutes for BioMedical Research
We are committed to discovering innovative medicines to cure disease and improve human health. By hiring the best academic, biotech, and pharmaceutical trained scientists, we have fostered an atmosphere for drug discovery where innovation is rewarded. |
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An Emerging Revolution in Automated 3D Cell Culture
Merck Research Laboratories,University of Virginia, BioCell Cubed
Market pressure exists for new paradigms to meet the demands for more rapid and reproducible cell production to keep up with advances in cell-based assays used in drug discovery and development. Novel automation platforms enable high productivity on three dimensional surfaces. |
Development of a Lab-on-a-Chip for the Characterization of Human Cells
ARC and Nano-Systemtechnologies
Cell chips are developed to continuously monitor mammalian cell population dynamics in a non-invasive manner. In the presented work we describe the design, fabrication and characterization of a lab-on-a-chip for quantitative cell analysis. |
Bio-analytic silicon chips for the detection of developmentalneurotoxic effects of chemicals and drugs in the context of the European REACH program
University of Rostock, Bionas GmbH
Bio-analytic silicon chips can be used to investigate stem cell differentiation into neurons and for the in vitro on-line monitoring of cellular reactions under well controlled experimental conditions. Chip systems allow for a parallel, label-free and non-invasive measurement of different parameters by CMOS silicon microsensors by the application of potential neurotoxic and developmental neurotoxic substances. |
RNA Interference in Mammalian Cells Using low siRNA Concentrations
QIAGEN
We have developed a transfection reagent, HiPerFect Transfection Reagent, which allows efficient gene knockdown with siRNA concentrations from 1 nM–10 nM, depending on the cell type and siRNA used. HiPerFect Transfection Reagent has been tested and validated for many cell types, including primary cells. Effective knockdown in primary cells demonstrates that HiPerFect Transfection Reagent ensures low cytotoxicity levels. |
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6th Annual International Predictive Human Toxicity and ADME/Tox Studies Conference
Mondial Research Group
Mondial Research Group will be offering three of our most popular
training courses. These courses will be offered in three different
locations facilitating easier accessibility for participation. |
6th Compound Management & Integrity Summit
IQPC
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Stem Cells USA & Regenerative Medicine Congress 2010
Terrapinn
Stem Cells USA & Regenerative Medicine Congress brings together industry leaders from big pharma, biotechs, government and research organizations to address the opportunities and challenges for commercialization of stem
cells and regenerative medicine. For more information, please go to www.terrapinn.com/2010/stemcellsusa. |
Gene Based Vaccines: Optimising Development and Delivery
Marcus Evans
Analysing novel vaccine design and delivery methods in order to translate evidence into clinical success.
Further developments in electroporation and other novel delivery methods have changed the vaccines landscape. Therefore, this year we will be evaluating the newly developed delivery techniques and how to overcome the challenges faced. |
World Pharma Trials Asia 2010
Terrapinn
World Pharma Trials Asia is the only Asia-focused event in China in 2010, where the world’s top pharmas, biotechs, CROs, and regulators convene to provide the most comprehensive knowledge into the best operational strategies and practices in fast-tracking clinical drug developments.
Chua Yee Ling
+65 6322 2757
yeeling.chua@terrapinn.com |
RNAi & miRNA Europe
Select Biosciences Ltd
Now in its 7th year, our popular RNAi Europe conference will be co-located with three others to cover the broad spectrum of RNA research. This year there will be a large focus on the latest research in microRNAs as well as RNAi in cancer and other diseases. |
Advances in qPCR
Select Biosciences Ltd
Now in its 3rd year, this conference will discuss the latest techniques and platforms for qPCR as well as highlighting some of the uses of qPCR for current research including Biomarker Discovery, Medical Diagnostics and Profiling and microRNA and siRNA studies. |
Epigenetics Europe
Select Biosciences Ltd
The second Epigenetics Europe will focus on the most recent discoveries in this field. Speakers will discuss Methylation and DNA silencing, Chromatin remodelling and ncRNA functions as well as highlighting some of the discoveries of epigenetics in disease processes. |
14th International Biotechnology Symposium and Exhibition
Join international delegates for the 14th International Biotechnology Symposium and Exhibition ‘Biotechnology for the Sustainability of Human Society’, 14-18 September 2010 at the Palacongressi, Rimini, Italy.
Full programme information for the 10 topical sections is available to view at www.ibs2010.org |
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