Award Winner
« Back
Lisa Mutschelknaus wins Best Poster Award at Extracellular Vesicles 2016
Lisa Mutschelknaus wins Best Poster Award at Extracellular Vesicles 2016

This study indicates a functional role for exosomes in the response of tumor cells to therapeutic radiation exposure, suggests that radiotherapy modified exosomes influence the cancer progression and encourages that exosomes might be a useful tool to improve therapy strategies.
Poster
Exosomes promote survival in squamous head and neck cancer cells after ionizing radiation
Exosomes promote survival in squamous head and neck cancer cells after ionizing radiation
Lisa Mutschelknaus, Carsten Peters, Klaudia Winkler, Ramesh Yentrapalli, Theresa Heider, Michael J. Atkinson, Simone Moertl
Helmholtz Zentrum München, Institute of Radiation Biology, Neuherberg, Germany / Department of Chemistry, Technical University of Munich, Munich, Germany
Poster Views: 1,944
view poster »
Poster Abstract
Exosomes were isolated from conditioned medium of irradiated as well as non-irradiated head and neck cancer cells (BHY and FaDu) by serial ultracentrifugation. Quantification by NanoSight technology indicates an increased exosome release from irradiated compared to non-irradiated cells 24 hours after treatment. To test whether the released exosomes influence the radiation response, exosomes isolated from non-irradiated and irradiated donor cells were transferred on non-irradiated and irradiated recipient cells. We find an enhanced uptake of exosomes, when transferred to irradiated recipient cells compared to the transfer to non-irradiated cells. Functional analyses after exosome transfer indicate that exosomes increase not only the proliferation but also the survival after irradiation in recipient cells. These findings mesh with an increased DNA double strand break repair after the transfer of exosomes isolated from irradiated cells.
Our results demonstrate that radiation increases exosome abundance and influences their effects on recipient cells. This study indicates a functional role for exosomes in the response of tumor cells to therapeutic radiation exposure, suggests that radiotherapy modified exosomes influence the cancer progression and encourages that exosomes might be a useful tool to improve therapy strategies.


Related Posters


CPAP TEMPRANO EN RN PRE TÉRMINO CON SÍNDROME DE DISTRÉS RESPIRATORIO, NEONATOLOGÍA, HOSPITAL METROPOLITANO, QUITO. 2013-2015
Irene Carrillo Mayanquer, Paola Elizabeth Basantes Torres, Fernando Aguinaga Romero,

Uso de la ventilación mecánica no invasiva y su relación con el distres respiratorio del recien nacido
Irene Carrillo Mayanquer, Paola Elizabeth Basantes Torres, Fernando Aguinaga Romero, Fernando Agama, Freud Càceres

A new Windowed Graph Fourier Transform
Le Trung-Thanh; Nguyen Linh-Trung; Tran Thi Thuy-Quynh;

Electrophysiological and cardiotoxicological characterization of human iPSC-derived cardiomyocytes (hiPSC-CMs) in 3D microtissues and 2D monolayers
Hortigon-Vinagre, Maria P. 1,2 ; Zamora, Victor1,2 ; Mamta Chabria3 ; Liudmila Polonchuk3 ; Bucerius, Roman4; Burton, Francis. L.1,2 ; Smith, Godfrey L.1,2

Immediate effect on neural mobilization on nerve excitability in a normal subject A case study
Prof Subin Solomen, Mohammed Shafeeq, Mehar Jesiya V

 
Keep up to date
with the latest posters
Receive World Wide Exposure
Increase Collaboration
Close
Close
Premium CrownJOIN THE EPOSTERS COMMUNITY!