Label-free cell-based on-line monitoring of cells in the focus of pharmacological in vitro studies

, Bionas GmbH

The Bionas® 2500 analyzing system provides a non-invasive, multiparametric
and label-free monitoring of cellular metabolic parameters
like extracellular acidification and oxygen consumption as well as cell
impedance/adhesion.
The method integrates the investigation of the dynamic cell behaviour
influenced by test compounds, including cytotoxic and dose-dependent
effects in addition to regeneration effects after treatment and removal of
test compounds. By generating profiles of bioenergetics and cell
morphology, the system monitors the action of substances in the area
of toxicology, drug discovery and oncology, respectively. In the focus of
quality management procedures, the standardization and optimization
of cell culturing and media composition is another application.
The evaluation of effects of pharmaceuticals and compounds are
investigated on a cellular level by monitoring the metabolic status of the
cell. Changes of acidification activity and mitochondrial respiration
caused by test substances are hints for effects on cellular physiology
and presumably the cytotoxic property of the substance used. From
these observations one can deduce the targeted metabolic functions.
Taken together, the Bionas® 2500 analyzing system presents a
beneficial technology for the analysis of multi-parametric monitoring of
cellular processes.

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