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Devyani Swami wins Budding Drug Discovery Scientist Award at the Drug Discovery India 2014 conference
Devyani Swami wins Budding Drug Discovery Scientist Award at the Drug Discovery India 2014 conference

Standard treatment for ‘Nerve Agents’ or Organophophorus compounds (OP) poisoning involves atropinization and oxime administration. Presently used Oximes do not readily cross blood-brain barrier, thus reactivation of brain Acetylcholinesterase enzyme (AChE) remains vague. It is still debatable whether ‘AChE inhibition is the sole cause of OP toxicity’. HNK series of new oximes were synthesized and LD50 determined following intramuscular and subcutaneous routes of administration respectively.
Poster
<i>In vivo</i> Protective efficacy of new bis-quaternary oximes against Diisopropylphosphorofluoridate (DFP) poisoning in Swiss male mice
In vivo Protective efficacy of new bis-quaternary oximes against Diisopropylphosphorofluoridate (DFP) poisoning in Swiss male mice
Devyani Swami, H.N.Karade, J.R.Acharya, M.K.Meena, Pravin Kumar
Pharmacology & Toxicology Divison, Defence R&D Establishment, Jhansi Road, Gwalior- 474002 (M.P.), India
Poster Views: 3,526
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Poster Abstract
Standard treatment for 'Nerve Agents' or Organophosphorus compounds (OP) poisoning involves atrpoinization and oxime administration. Presently used oximes do not readily cross blood- brain barrier, thus reactivation of brain Acetylcholinesterase enzyme (AChE) remains vague. Secondly, it is still debatable whether 'AChE inhibition is the sole cause of OP toxicity'. HNK series of new oximes were synthesized and LD 50 determined following intramuscular and subcutaneous routes of administration respectively, in Swiss albino mice. Various doses of DFP, the oximes (dose corresponding to their 0.05, 0.10, and 0.20 LD 50, i.m.) and atrpoine (10mg/kg, i.p.) were administered and Protection Index (PI) determined. DFP induced IC 50 of AChE was determined 60 minutes (optimized time) post exposure in brain and serum. Shift of IC 50 or reactivation of AChE following oximes treatment illustrated that HNK-102 and HNK-106 reactivated brain AChE, significantly higher (p<0.01) compared to that of 2-Pralidoxime (PAM),in vivo. In protection studies, HNK-102 and HNK-106 alos showed far better results (p<0.05) compared to PAM in vivo
Keywords: DFP, Oximes, AChE reactivator, HNK-102, HNK-106

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