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131:Paraneoplastic Pemphigus Associated With B-Cell Lymphoma A Case Report[AAOM2021]
EP36045
Poster Title: 131:Paraneoplastic Pemphigus Associated With B-Cell Lymphoma A Case Report[AAOM2021]
Submitted on 29 Mar 2021
Author(s): Loulwah Alothman1, Bayan Jamal1, Sara Aldosary1, Nuha Alfurayh2, Azizah Bin Mubayrik1, Abdulmajeed Alajlan2
Affiliations: 1: Department Oral Medicine & Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia; 2: Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
This poster was presented at 2021 American Academy of Oral Medicine Virtual Conference
Poster Views: 431
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Poster Information
Abstract: Background:

Paraneoplastic pemphigus is a rare life threatening auto-immune mucocutaneous disease associated with various neoplasms.

Case summary:

We report a case of a sixty-one years old male patient who presented to the ER department on June 2020 complaining of severe inflammation of the left eye along with scaly erythematous skin eruptions affecting hands, trunk and feet. Upon further clinical examination the patient had extensive oral ulceration involving the dorsum and ventral surface of the tongue, buccal mucosa, labial mucosa, scaly erythematous papules were noticed on the lips. Lesions were associated with a significant unintentional weight loss and loss of appetite. The patient was admitted to our hospital for full workup including malignancy screening. Histopathological examination of skin lesions was consistent with paraneoplastic pemphigus. After screening for malignancy, the patient was found to have a huge retroperitoneal mass. . CT guided biopsy from the tumor confirmed the diagnosis of low-grade B cell non-Hodgkin's lymphoma. The patient was then referred to hematology-oncology team. During his hospital admission, the patient received prednisone 60 mg/day orally for 5 days but oral lesions were resistant. Oral lesions were managed by the oral medicine team with oral rinse prednisolone and tetracycline, and lip lesions were treated using betamethasone & Fucidic acid ointments. This have resulted in a better lesion response and improved the ability of oral intake by the patient which retained a significant positive impact on the patient’s satisfaction and quality of life.

Conclusions:

This report, highlights the importance of collaborative holistic approach especially for serious conditions affecting wellbeing. A multidisciplinary approach to achieve early diagnosis, prevention and better management is essential to improve the quality of life for such patients despite the poor prognosis
Summary: Paraneoplastic pemphigus (PNP) was first described by Anhalt et al . It is a rare life threatening auto-immune mucocutaneous disease associated with underlying neoplasms and characterized by several clinical presentation. Patients may have pemphigoid like lesions, erosions and crusting. Head and neck region, trunk and proximal extremities are most commonly affected.

Ask the author questions about this poster:loalothman@ksu.edu.sa
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