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178:Medications Commonly Associated With Oral Lichenoid Lesions: A Single-site Retrospective Cohort Study[AAOM2020]
EP36096
Poster Title: 178:Medications Commonly Associated With Oral Lichenoid Lesions: A Single-site Retrospective Cohort Study[AAOM2020]
Submitted on 29 Mar 2021
Author(s): Sara Sternbach1, Juliana Gomez2, Sonal Shah3, Debra Fischoff3
Affiliations: 1: Department of Oral and Maxillofacial Pathology, Long Island Jewish Medical Center; 2: Department of Oral and Maxillofacial Surgery, University of Florida Jacksonville; 3: Department of Oral and Maxillofacial Pathology, Radiology and Medicine, New York University College of Dentistry
This poster was presented at 2021 American Academy of Oral Medicine Virtual Conference
Poster Views: 227
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Poster Information
Abstract: OBJECTIVE

While treating patients with oral lichen planus (OLP) or oral lichenoid lesions (OLL) in the New York University College of Dentistry Oral Medicine clinic, we noted that many patients were taking anti-hyperlipidemic and / or thyroid medications. Therefore, we decided to determine the incidence of these medications taken in patients with OLP or OLL.

METHODS

After obtaining IRB approval, study personnel performed retrospective chart review for diagnoses, “oral lichen planus,” “lichenoid mucositis,” and “lichenoid drug reaction” over a five-year time period at the NYUCD Oral Medicine clinic. Patients were evaluated for medical conditions and prescription medications recorded in the electronic health record. Data points such as age, gender, and initial presentation to the Oral Medicine clinic were recorded for each patient. Patients with other biopsy-proven vesiculo-erosive conditions were excluded. Qualitative analysis was performed regarding study subjects.

RESULTS

From our institutional chart review, a total of 162 patients were identified with 109 females (67%) and 53 males (33%). Patient’s ages ranged from 26 to 88 years, with the average age being 59.5 years. As found in other studies, the top two classes of medications were anti-hypertensives (49%) and anti-hyperlipidemic (35%). Furthermore, a strong representation of patients taking medications for hypothyroidism was found. We were able to identify specific medications and in our patient population, 34% of patients were taking statin medications, specifically 15% of patients took atorvastatin and 9% took simvastatin. We also discovered that 24% of our study patients were taking metformin, 17% taking proton pump inhibitors, and interestingly, 16% taking levothyroxine. When we separated the anti-hypertensive medications by class: 18% of patients took beta blockers, 17% took Angiotensin II receptor blockers, 17% took calcium channel blockers, 15% took ACE inhibitors, and 11% took thiazide diuretics.

CONCLUSION

Although this study does not prove causality, there was a strong representation of OLL and OLP patients treated in our clinic that were taking anti-hypertensive, anti-hyperlipidemic, diabetes, thyroid, and GERD medications. This emphasizes the importance of clinicians being more aware of the potential adverse reactions that patients taking these medications may experience to better prepare them for managing and treating lichenoid conditions.
Summary: While treating patients with oral lichen planus (OLP) or oral lichenoid lesions (OLL) in the New York University College of Dentistry Oral Medicine clinic, we noted that many patients were taking anti-hyperlipidemic and / or thyroid medications. Therefore, we decided to determine the incidence of these medications taken in patients with OLP or OLL.

Ask the author questions about this poster:dkf1@nyu.edu
References: 1. Al-Hashimi I, Schifter M, Lockhart PB, et al. Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103(suppl:S25):e1–e12. doi:10.1016/j.tripleo.2006.11.001
2. Thornhill MH, Pemberton MN, Simmons RK, Theaker ED. Amalgam-contact hypersensitivity lesions and oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(3):291–299.doi:10.1067/moe.2003.115
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5. Nogueira PA, Carneiro S, Ramos-e-Silva M. Oral lichen planus: an update on its pathogenesis. Int J Dermatol. 2015;54(9):1005–1010. doi:10.1111/ijd.12918
6. Lodi G, Pellicano R, Carrozzo M. Hep
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