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2D FT-ICR MS/MS analysis of IgG1
EP30775
Poster Title: 2D FT-ICR MS/MS analysis of IgG1
Submitted on 10 Oct 2019
Author(s): Johanna Paris 1 , Tomos E. Morgan 1 , Yuko P. Y. Lam 1 Christopher A. Wootton 1 Mark André Delsuc 2 , Mark P. Barrow 1 , John O’Hara 3 , and Peter B. O’Connor 1
Affiliations: 1. ICR lab, University of Warwick, CV4 7AL, Coventry, UK 2. 3IGBMC, Illkirch Graffenstaden , France 3. UCB, SL1 3WE, Slough, UK
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Abstract: Recombinant monoclonal antibodies and derivatives are widely used as therapeutic drugs They are susceptible to post translational modifications that could occur during the manufacturing process and storage, resulting in product related impurities PTMs can change the efficacy, toxicity, or the clearance of the antibody therefore they need to be well monitored.Summary: Recombinant monoclonal antibodies and derivatives are widely used as therapeutic drugs They are susceptible to post translational modifications that could occur during the manufacturing process and storage, resulting in product related impurities PTMs can change the efficacy, toxicity, or the clearance of the antibody therefore they need to be well monitored.References: [1] Amster , I. J., Fourier transform mass spectrometry. J. Mass Spectrom. 1996, 31 (12), 1325 1337
[2] Tsybin , Y. O.; Witt, M.; Baykut , G.; Kjeldsen , F.; Håkansson , P., Combined infrared multiphoton dissociation and electron capture dissociation with a hollow electron beam in Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun . Mass Spectrom. 2003, 17 (15), 1759 1768.
[3] Pfändler , P.; Bodenhausen , G.; Rapin , J.; Houriet , R.; Gäumann , T., Two dimensional Fourier transform ion cyclotron resonance mass spectrometry. Chem. Phys. Lett. 1987, 138 (2 3), 195 200
[4] Flora, J. W.; Muddiman , Selective , sensitive, and rapid phosphopeptide identification in enzymatic digests using ESI FTICR MS with infrared multiphoton dissociation. Anal Chem. 2001 , 73 (14), 3305 3311
[5] Flora, J. W.; Muddiman , Gas phase ion unimolecular dissociation for rapid phosphopeptide mapping by IRMPD in a penning ion trap: An energetically favored process. JACS 2002
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