We've updated our Privacy Policy to make it clearer how we use your personal data.
We use cookies to provide you with a better experience, read our Cookie Policy
EP30775
Poster Title: 2D FT-ICR MS/MS analysis of IgG1
Submitted on 10 Oct 2019
Author(s): Johanna Paris 1 , Tomos E. Morgan 1 , Yuko P. Y. Lam 1 Christopher A. Wootton 1 Mark André Delsuc 2 , Mark P. Barrow 1 , John O’Hara 3 , and Peter B. O’Connor 1
Affiliations: 1. ICR lab, University of Warwick, CV4 7AL, Coventry, UK 2. 3IGBMC, Illkirch Graffenstaden , France 3. UCB, SL1 3WE, Slough, UK
Poster Views: 845
Please be aware that this Poster is viewable on an external site.
Submitted on 10 Oct 2019
Author(s): Johanna Paris 1 , Tomos E. Morgan 1 , Yuko P. Y. Lam 1 Christopher A. Wootton 1 Mark André Delsuc 2 , Mark P. Barrow 1 , John O’Hara 3 , and Peter B. O’Connor 1
Affiliations: 1. ICR lab, University of Warwick, CV4 7AL, Coventry, UK 2. 3IGBMC, Illkirch Graffenstaden , France 3. UCB, SL1 3WE, Slough, UK
Poster Views: 845
Please be aware that this Poster is viewable on an external site.
Abstract: Recombinant monoclonal antibodies and derivatives are widely used as therapeutic drugs They are susceptible to post translational modifications that could occur during the manufacturing process and storage, resulting in product related impurities PTMs can change the efficacy, toxicity, or the clearance of the antibody therefore they need to be well monitored.Summary: Recombinant monoclonal antibodies and derivatives are widely used as therapeutic drugs They are susceptible to post translational modifications that could occur during the manufacturing process and storage, resulting in product related impurities PTMs can change the efficacy, toxicity, or the clearance of the antibody therefore they need to be well monitored.References: [1] Amster , I. J., Fourier transform mass spectrometry. J. Mass Spectrom. 1996, 31 (12), 1325 1337
[2] Tsybin , Y. O.; Witt, M.; Baykut , G.; Kjeldsen , F.; Håkansson , P., Combined infrared multiphoton dissociation and electron capture dissociation with a hollow electron beam in Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun . Mass Spectrom. 2003, 17 (15), 1759 1768.
[3] Pfändler , P.; Bodenhausen , G.; Rapin , J.; Houriet , R.; Gäumann , T., Two dimensional Fourier transform ion cyclotron resonance mass spectrometry. Chem. Phys. Lett. 1987, 138 (2 3), 195 200
[4] Flora, J. W.; Muddiman , Selective , sensitive, and rapid phosphopeptide identification in enzymatic digests using ESI FTICR MS with infrared multiphoton dissociation. Anal Chem. 2001 , 73 (14), 3305 3311
[5] Flora, J. W.; Muddiman , Gas phase ion unimolecular dissociation for rapid phosphopeptide mapping by IRMPD in a penning ion trap: An energetically favored process. JACS 2002
[2] Tsybin , Y. O.; Witt, M.; Baykut , G.; Kjeldsen , F.; Håkansson , P., Combined infrared multiphoton dissociation and electron capture dissociation with a hollow electron beam in Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun . Mass Spectrom. 2003, 17 (15), 1759 1768.
[3] Pfändler , P.; Bodenhausen , G.; Rapin , J.; Houriet , R.; Gäumann , T., Two dimensional Fourier transform ion cyclotron resonance mass spectrometry. Chem. Phys. Lett. 1987, 138 (2 3), 195 200
[4] Flora, J. W.; Muddiman , Selective , sensitive, and rapid phosphopeptide identification in enzymatic digests using ESI FTICR MS with infrared multiphoton dissociation. Anal Chem. 2001 , 73 (14), 3305 3311
[5] Flora, J. W.; Muddiman , Gas phase ion unimolecular dissociation for rapid phosphopeptide mapping by IRMPD in a penning ion trap: An energetically favored process. JACS 2002
Ask the author a question about this poster.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Related Posters
Crosslinking & Label Transfer Protein Interaction Analysis
Creative Proteomics
Introduction to Circular Dichroism
Creative Proteomics
What NMR can do in the biopharmaceutical industry?—Creative Proteomics
Creative Proteomics
A streamlined workflow for the quality control, interpretation and analysis of timsTOF Pro data: towards large-scale proteomics
Chengpin Shen1, Xianming Liu2, Xiaoxian Du2, Xiaoqing Wang1, Hebin Liu1 and Ruoyu Wu2 1 Omicsolution Co., Ltd, Shanghai, China 2 Bruker Daltonics, Shanghai, China
CCS-centric protein identification using IM Score
Robin Park1, Patrick Garrett3, Sven Brehmer2, Titus Jung3, Vijayaraja Gnanasambandan1, Marc-Antoine Beauvais1, Sebastian Wehner2, Lennard Pfennig2, Hyunsoo Kim3, Christopher Adams1, Dennis Trede2, John R. Yates, III3, Rohan Thakur1 1Bruker Daltonics Inc., USA 2Bruker Daltonik GmbH, Bremen, Germany 3Scripps Research, San Diego, USA
