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4D Lipidomics workflow utilizing PASEF acquisition mode for increased throughput
EP38445
Poster Title: 4D Lipidomics workflow utilizing PASEF acquisition mode for increased throughput
Submitted on 09 Mar 2022
Author(s): Florian Zubeil 1 , Ansgar Korf 1 , Viola Jeck 1 , Aiko Barsch 1 , Nikolas Kessler 1 , Sven W. Meyer 1
Affiliations: 1 Bruker Daltonics GmbH & Co. KG, Bremen, Germany
Poster Views: 454
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Poster Information
Abstract: Lipids represent a biological compound class with a broad variety of chemical structures Their essential biological roles make them interesting biomarkers in clinical research [1]. However, confident lipid annotation can be time consuming, and it requires an unambiguous dif-ferentiation of co-elution isobaric and isomeric compounds. The presented 4 D Lipidomics workflow for increased throughput simplifies and streamlines the annotation and validation process using mobility enhanced MS data.Summary: The presented 4 D Lipidomics workflow for increased throughput simplifies and streamlines the annotation and validation process using mobility enhanced MS data.References: [1] Züllig et al. (2020), Mass Spectrom. Rev., early view.
[2] Matyash (2008), V. et al., J. Lipid Res., 49, 1137-1146
[3] Application Note LCMS-158, Using Parallel Accumulation Serial Fragmentation (PASEF) to speed up untargeted 4D lipidomics LC MS/MS workflows.
[4] Application Note LCMS-175, Investigating the increased lifespan in C.elegans daf 2 mutants by 4D Lipidomics.
[5] Tsugawa et al. (2020), Nature Biotechnology, 38, 1159-1163.
[6] Hayen et al. (2018), Rapid Commun. Mass Spectrom., 32, 981-991.
[7] Liebisch et al., The Journal of Lipid Research, 61, 1539
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