Posters
« Back
The Inhibition Pathways of Human Islet Amyloid Polypeptide
EP31018
Poster Title: The Inhibition Pathways of Human Islet Amyloid Polypeptide
Submitted on 22 Nov 2019
Author(s): Yuko P. Y. Lam1; Cookson K.C. Chiu1; Christopher A. Wootton1; Ji-Inn Song1; Meng Li1; Ian Hands-Portman2; Mark P. Barrow1; and Peter B. O'Connor1
Affiliations: 1 Department of Chemistry, University of Warwick, Coventry, UK 2 School of Life Science, University of Warwick, Coventry, UK
Poster Views: 374
View poster »

Please be aware that this Poster is viewable on an external site.


Poster Information
Abstract: Human islet amyloid polypeptide (hIAPP) is a highly amyloidogenic protein

Amyloid proteins are inherently disordered with high conformation flexibility 1-2

Classic structure-based design for therapeutics drug development against amyloid proteins is challenging 3

Herein, mass spectrometry was used to identify binding regions of a range of reported hIAPP aggregation inhibitors, including human
insulin, (-)-Epigallocatechin 3-gallate (EGCG), 3-amino-1-propane sulfonic acid (3-APS), and 1H-Benzimidazole-2-sulfonic acid (BISA)

Deamidated hIAPP accelerates amyloid fibril formation,4 but the interactions with reported aggregation inhibitors are unknown
Summary: Human islet amyloid polypeptide (hIAPP) is a highly amyloidogenic proteinReferences: 1. Chiti, F.; Dobson, C. M.. In Annu. Rev. Biochem, Annual Reviews: Palo Alto, 2006; Vol. 75, pp 333-366.
2. Knowles, T. P.; Vendruscolo, M.; Dobson, C. M..Nat. Rev. Mol. Cell Biol. 2014, 15 (6), 384-396.
3. Hajduk, P. J.; Greer, J.. Nat. Rev. Drug Discovery 2007, 6 (3), 211-219.
4. YPY Lam; CA Wootton; I Hands-Portman, J Wei; CKC Chiu; I Romero-Canelon; F Lermyte; MP Barrow; PB O’Connor.
Chem. Comm. 2018, 54, 13853-13856
Report abuse »
Questions
Ask the author a question about this poster.
Ask a Question »

Creative Commons

Related Posters


Combining Imaging and OMICs: MALDI guided SpatialOMx probes proteomic mass profiles of breast cancer tumor subpopulations
Janina Oetjen 1 , Romano Hebeler 1 , Frédéric Dewez 2 , Corinna Henkel 1 , Benjamin Balluff 2 , Ron Heeren 2

Novel MALDI-TOF MS Workflow for Ultrahigh-Throughput Screening of Different Analytes at Each Position on a Plate
Sergei Dikler

FXa Anticoagulant Bioactive Proteins Derived from Scorpion Venom
Meng Li,1 Yuko P. Y. Lam,1 Peng Chen,2 Remy Gavard,1 Cookson K. C. Chiu,1 Christopher A. Wootton,1 Tomos E. Morgan,1 Qiong Wu,2 Mark P. Barrow,1 Hongzheng Fu,2 Peter B. O’Connor1

2D FT0ICR MS/MS analysis of IgG1
Johanna Paris 1 , Tomos E. Morgan 1 , Yuko P. Y. Lam 1 Christopher A. Wootton 1 Mark André Delsuc 2 , Mark P. Barrow 1 , John O’Hara 3 , and Peter B. O’Connor 1

High speed untargeted 4D-lipidomics LC-MS/MS workflows with Parallel Accumulation Serial Fragmentation (PASEF)
Ulrike Schweiger-Hufnagel1, Aiko Barsch1, Sven W. Meyer1