« Back
The Inhibition Pathways of Human Islet Amyloid Polypeptide
Poster Title: The Inhibition Pathways of Human Islet Amyloid Polypeptide
Submitted on 22 Nov 2019
Author(s): Yuko P. Y. Lam1; Cookson K.C. Chiu1; Christopher A. Wootton1; Ji-Inn Song1; Meng Li1; Ian Hands-Portman2; Mark P. Barrow1; and Peter B. O'Connor1
Affiliations: 1 Department of Chemistry, University of Warwick, Coventry, UK 2 School of Life Science, University of Warwick, Coventry, UK
Poster Views: 708
View poster »

Please be aware that this Poster is viewable on an external site.

Poster Information
Abstract: Human islet amyloid polypeptide (hIAPP) is a highly amyloidogenic protein

Amyloid proteins are inherently disordered with high conformation flexibility 1-2

Classic structure-based design for therapeutics drug development against amyloid proteins is challenging 3

Herein, mass spectrometry was used to identify binding regions of a range of reported hIAPP aggregation inhibitors, including human
insulin, (-)-Epigallocatechin 3-gallate (EGCG), 3-amino-1-propane sulfonic acid (3-APS), and 1H-Benzimidazole-2-sulfonic acid (BISA)

Deamidated hIAPP accelerates amyloid fibril formation,4 but the interactions with reported aggregation inhibitors are unknown
Summary: Human islet amyloid polypeptide (hIAPP) is a highly amyloidogenic proteinReferences: 1. Chiti, F.; Dobson, C. M.. In Annu. Rev. Biochem, Annual Reviews: Palo Alto, 2006; Vol. 75, pp 333-366.
2. Knowles, T. P.; Vendruscolo, M.; Dobson, C. M..Nat. Rev. Mol. Cell Biol. 2014, 15 (6), 384-396.
3. Hajduk, P. J.; Greer, J.. Nat. Rev. Drug Discovery 2007, 6 (3), 211-219.
4. YPY Lam; CA Wootton; I Hands-Portman, J Wei; CKC Chiu; I Romero-Canelon; F Lermyte; MP Barrow; PB O’Connor.
Chem. Comm. 2018, 54, 13853-13856
Report abuse »
Ask the author a question about this poster.
Ask a Question »

Creative Commons

Related Posters

CCS-centric protein identification using IM Score
Robin Park1, Patrick Garrett3, Sven Brehmer2, Titus Jung3, Vijayaraja Gnanasambandan1, Marc-Antoine Beauvais1, Sebastian Wehner2, Lennard Pfennig2, Hyunsoo Kim3, Christopher Adams1, Dennis Trede2, John R. Yates, III3, Rohan Thakur1 1Bruker Daltonics Inc., USA 2Bruker Daltonik GmbH, Bremen, Germany 3Scripps Research, San Diego, USA

Real-time search of Ubiquitin diGLY modified peptides and PaSER acquisition control on the timsTOF PRO
Christopher Adams1; Robin Park1; Nagarjuna Nagaraj4; Sven Brehmer4; Matt Willetts3; Elizabeth Gordon3; Barry M. Zee2; Hayley Peckham2; Kimberly Lee2; Tharan Srikumar3 1Bruker,San Jose,CA;2Cell Signaling Technologies, Danvers, MA;3Bruker, Billerica, MA; 4Bruker, Bremen, Germany

Mass Spectrometry
Alfa Chemistry Testing Lab

Targeted Dereplication of Microbial Natural Products by High-Resolution MS and Predicted LC Retention Time
Chervin J,1 Stierhof M,1 Tong MH,1 Peace D,1 Hansen KØ,2 Urgast DS,1 Andersen JH,2 Yu Y,3 Ebel R,1 Kyeremeh K,4 Paget V,5 Cimpan G,5 Van Wyk A,5 McKee M,5 Deng H,1 Jaspars M,1 Tabudravu JN1

Efficient Management of Extractable & Leachable Data in Process Development
Sanji K. Bhal, Joe DiMartino