Posters
« Back
A CASE SERIES ON OCULAR MANIFESTATIONS IN STEVEN JOHNSON SYNDROME AND THEIR VARIED PRESENTATION-REVIEW OF LITERATURE
EP31089
Poster Title: A CASE SERIES ON OCULAR MANIFESTATIONS IN STEVEN JOHNSON SYNDROME AND THEIR VARIED PRESENTATION-REVIEW OF LITERATURE
Submitted on 14 Dec 2019
Author(s): 1. Dr Nagalakshmi Narayana-Swamy, 2. Dr Alhaj Farhath Tasneem
Affiliations: 1. PG resident Ophthalmology 2. Professor of Ophthalmology VYDEHI INSTITUTE OF MEDICAL SCIENCES AND RESEARCH CENTER
This poster was presented at CME ON PHARMACOVIGILANCE
Poster Views: 254
View poster »


Poster Information
Abstract: INTRODUCTION: Steven-Johnson syndrome is a rapidly progressive muco-cutaneous reaction occurring secondary to drugs,viral infections etc.

CASE-DESCRIPTION: Three Patients aged 9, 15, 43 years females with Steven-Johnson Syndrome secondary to various agents were reviewed for severity of ocular involvement. These patients presented with fever, skin rash, sloughing of skin, erythematous macules with ocular presentation of variable severity. All patients had mild-moderate lid edema, conjunctival injection, chemosis & membranous conjunctivitis with discharge.

DISCUSSION: Steven Johnson syndrome is a severe life threatening muco-cutaneous hypersensitivity reaction causing intraepidermal cell death.Ocular surface involvement is seen in 80% of the cases. Identification of the causative agent,reporting of such an adverse event and initial intervention aids saving the vision.
Summary: Steven Johnson have a wide spectra of ocular manifestations.They have a wide variety of presentation and various treatment modalities.Appropriate intervention during acute ocular presentation and careful intervention aids management.References: 1. Burns T, Breathnach S, Cox N, Griffiths C. Rooks Textbook of Dermatology. 7th edition Oxford: Blackwell Science; 2004. P, 53.1-53.47.

2. Bianchine JR, Macareg PV, Lasang LI, Azarnff DL.Brunk SF, Hvidberg EF, et al.Drugs as Histological factors in SJ Syndrome. Am J Med.1968; 44: 390-45.

3. Beedimoni RS, Rabhimaiah S. Oral cholorquine – induced Stevens Johnson Syndrome. Indian J Pharmacol. 2004;36:1

4. Stewart MG, Duncan NO 3rd,Frankin DJ, Friedman EM, Sulek M. Head and neck manifestations of erythema multiforme in children. Otolaryngol Head Neck Surg. 1994; 111: 236-42.

5. Tugboat, Satake Y,Kaido M, Shinozaki N, Shimmura S,Bissen-Miyajima H, et al. Treatment of severe ocular surface disorders with corneal epithelial stem-cell transplantation. N Engl J Med.1999; 340:1697-703.


6. Shimazaki Y,Yang H-Y,Tsubota Amniotic membrane transplantation for ocular surface reconstruction in patients with thermal and chemical burns.Ophthalmology.1997
Report abuse »
Questions
Ask the author a question about this poster.
Ask a Question »

Creative Commons