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A Novel Benchtop Time-of-Flight GC-MS System for High Throughput Qualitative and Quantitative Analysis of Drugs of Abuse in Human Urine
Poster Title: A Novel Benchtop Time-of-Flight GC-MS System for High Throughput Qualitative and Quantitative Analysis of Drugs of Abuse in Human Urine
Submitted on 13 Sep 2016
Author(s): Khai Pham, David E. Alonso, Christina Kelly, and Joe Binkley
Affiliations: LECO Corporation
This poster was presented at IMSC 2016
Poster Views: 1,057
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Poster Information
Abstract: Illicit drug use by teenagers and young adults continues to increase in the United States. Drug abuse is costly to our nation, exacting more than $700 billion annually in costs related to crime, lost work productivity, and health care. At the same time, many forensic laboratories are experiencing increased workloads and reduced resources. There is an immediate need for high throughput methods resulting in conclusive identification of controlled substances such as opiates, barbiturates, and amines. In this study, preparation and analysis times were significantly reduced without sacrificing thorough characterization of samples.
Summary: -High performance GC-TOFMS analysis facilitated drug identification through the acquisition of full range, non-skewed mass spectral data.
-Detection limits of non-derivatized drugs were well below the government cut-off levels.
-Runtime for barbiturates, opiates, and amines are under 10 minutes.
-Excellent calibration linearity with a concentration range from 5 ng/mL to 1000 ng/mL for opiates, barbiturates, and amines.
References: [1]Pizzo, Pat. "INTERPERTATION OF DRUG TEST RESULTS." National Association of Drug Court Professionals. N.p., 2015. Web. 03 Aug. 2016Report abuse »
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