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A novel multi-organ microfluidic chip: on the way to the complexity of a living organism
EP22820
Poster Title: A novel multi-organ microfluidic chip: on the way to the complexity of a living organism
Submitted on 17 Mar 2015
Author(s): Timur R Samatov, Svetlana A Tonevitskaya, Natalya Pulkova, Evgeny A Tonevitsky
Affiliations: Hemule GmbH
This poster was presented at Lab-on-a-Chip & Microfluidics 2015
Poster Views: 3,197
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Poster Information
Abstract: Currently an increasing number of physiologically relevant organ-on-chip platforms are reported. Most of them are focused on modeling particular organs or their functional elements. Here we present H-chip, a novel platform capable of culturing up to six different organotypic models integrated into a single microfluidic circuit. The developed platform provides constant long-term circulation and automated replenishment of medium in the circuit. The key characteristics of the medium flow, including volumetric flow velocity and resulting shear stress, are similar to the ones found in a human organism. The medium flow-dependent increased cell viability of cultured cells supports the physiological relevance of the presented platform.Summary: A novel physiologically relevant multi-organ chip is developed capable of culturing up to six different organotypic models integrated into a single microfluidic circuit.References: Report abuse »
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