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A retrospective assessment of current practice for  palliative radiotherapy for soft tissue sarcomas in South East Scotland 2014-2019
EP34325
Poster Title: A retrospective assessment of current practice for palliative radiotherapy for soft tissue sarcomas in South East Scotland 2014-2019
Submitted on 29 Oct 2020
Author(s): Glanville L, Doyle E , Phillips ID, Hennessy A
Affiliations: Edinburgh Cancer Centre, Western General Hospital, NHS Lothian
This poster was presented at BIR Annual Congress 2020
Poster Views: 153
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Poster Information
Abstract: Aim:
Assess current practice for patients with soft tissue sarcomas (STS) managed with palliative radiotherapy in South East Scotland.

Background:
STS are a rare group of cancers. Patients with locally symptomatic disease, or unsuitable for curative management, may receive palliative radiotherapy. Royal College of Radiology recommend 30-day mortality in palliative radiotherapy as an indicator of avoidable harm, also used in audit at other centres.1, 2 We set a standard of <10%.

Methods:
We included all patients with details of palliative radiotherapy for STS from the South East Scotland Cancer registry 2014-2019.

Results:
Of 296 patients, 22 received palliative radiotherapy. 15 female: 7 male. Median age at diagnosis: 71 years (range 33-87). The most frequent histological subtypes were leiomyosarcoma (5/22) and undifferentiated (5/22).

Median time from diagnosis to treatment was 1 month (range 0-8). 17 patients received radiotherapy only. 5 also received chemotherapy, with 2 requiring initial emergency chemotherapy. The most common radiotherapy dose was 3000Gy in 10 fractions (36%).

30-day mortality rate (from treatment commencing) was 9.1% (2 patients). No patients receiving >10 fractions died within 30 days. 20 patients subsequently died, 2 remain in follow-up (17 and 36 months). Median time from treatment commencing to death: 7 months (range 0-30).

Conclusion:
30-day mortality rate was <10% and currently meeting our standard of care. Both patients who died within 30 days received 20Gy in 5 fractions. We recommend patients with poor prognosis be considered for single fraction treatment. As data is slowly accrued assessment of individual cases should be ongoing.
Summary: A retrospective assessment of current practice for palliative radiotherapy for soft tissue sarcomas in South East Scotland 2014-2019References: 1. Spencer K, Morris E, Dugdale E et al. 30 day mortality in adult palliative radiotherapy. Clinical oncology RCR. 2015. https://www.rcr.ac.uk/audit/30-day-mortality-following-adult-palliative-radiotherapy
2. DoH. Improving Outcomes: A Strategy for Cancer. Secondary Improving Outcomes: A Strategy for Cancer 2011. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/213785/dh_123394.pdf
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