Posters
« Back
A Unique Case of Hemochromatosis and Pancreatitis
EP38938
Poster Title: A Unique Case of Hemochromatosis and Pancreatitis
Submitted on 23 Jun 2022
Author(s): Magana Herrera, Fernando D.O , Fieker, Aaron D.O , Sharma, Niha Haresh MD
Affiliations: Oklahoma State University Medical Center Gastroenterology; Oklahoma State University Medical Center Internal Medicine
This poster was presented at Submitted to ACP National Conference
Poster Views: 190
View poster »


Poster Information
Abstract: Herein we present a unique case of hemochromatosis in a patient with recurrent chronic pancreatitis. Initially thought to be pancreatitis secondary to hypertriglyceridemia, this patient was placed on fenofibrate and was found to have a recurrence of acute pancreatitis with triglycerides within normal limits. This case highlights a patient with a family history of JAK2 gene mutation and found to have two copies of Cys 282Tyr variant and elevated iron stores as seen on laboratory studies. Common triggers for pancreatitis were explored and patient underwent a hepatic workup for mild transaminitis seen on admitting laboratory studies. Both Hematology and Gastroenterology services evaluated the patient, and she is undergoing therapeutic phlebotomy. She has also undergone Endoscopic Ultrasound imaging of her pancreas. There is limited data available regarding the association or causation of acute or chronic pancreatitis in the setting of Hereditary Hemochromatosis. This is a unique case presentation that further sheds a light on the need for continued research and evaluation regarding the association, role that hemochromatosis and iron overload plays in developing pancreatitis, and prevalence of hemochromatosis in patients with unexplained pancreatitis. Summary: Herein we present a unique case of hemochromatosis in a patient with recurrent chronic pancreatitis. Initially thought to be pancreatitis secondary to hypertriglyceridemia, this patient was placed on fenofibrate and was found to have a recurrence of acute pancreatitis with triglycerides within normal limits.References: -Murphree, C.R., Nguyen, N.N., Raghunathan, V., Olson, S.R., DeLoughery, T. and Shatzel, J.J. (2020), Diagnosis and management of hereditary haemochromatosis. Vox Sang, 115: 255-262. https://doi.org/10.1111/vox.12896

-Hitawala A, Alomari M, Khazaaleh S, Alomari A, Sanaka MR. Hemochromatosis As an Unusual Cause of Pancreatitis in an African-American Female of Child-bearing Age. Cureus. 2020;12(3):e7179. Published 2020 Mar 4. doi:10.7759/cureus.7179

-Bacon BR, Adams PC, Kowdley KV, Powell LW, Tavill AS; American Association for the Study of Liver Diseases. Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology. 2011;54(1):328-343. doi:10.1002/hep.24330

-Hucl, T., Kylanpää-bäck, ML., Witt, H. et al. HFE genotypes in patients with chronic pancreatitis and pancreatic adenocarcinoma. Genet Med 9, 479–483 (2007). https://doi.org/10.1097/GIM.0b013e3180986df4

-Syed, Asma MD;
Report abuse »
Creative Commons