Posters
« Back
Accelerated Ageing in Depression: A Study of Two Cohorts
EP30253
Poster Title: Accelerated Ageing in Depression: A Study of Two Cohorts
Submitted on 07 Jul 2019
Author(s): Mathew A. Harris, Laura de Nooij, Xueyi Shen, Toni-Kim Clarke, Riccardo Marioni, Simon R. Cox, Emma L. Hawkins, Mark J. Adams, Liana Romaniuk, Stephen M. Lawrie, James H. Cole, Andrew M. McIntosh and Heather C. Whalley
Affiliations: Division of Psychiatry / Department of Psychology, University of Edinburgh; Centre for Neuroimaging Science, King's College London
This poster was presented at OHBM 2019
Poster Views: 527
View poster »


Poster Information
Abstract: Major depressive disorder (MDD) is a severe psychiatric disorder associated with shortened lifespan and comorbidities of advancing age. Accelerated biological ageing may underlie these associations. We used brainageR (a machine learning package) to predict age from brain structure, then used the discrepancy between brain-predicted age and chronological age as an indicator of accelerated brain ageing and poorer brain health. In two cohorts, UK Biobank and STRADL, MDD cases showed slightly higher brain age. Effects were stronger when focusing on MDD cases who were using psychotropic medications, suggesting that these medications contribute to brain ageing acceleration. Alternatively, subjects on medication may represent more severe cases of MDD.
Summary: Depressed individuals had slightly older-appearing brains than controls. Medication was associated with greater brain ageing acceleration.
References: Report abuse »
Questions
Ask the author a question about this poster.
Ask a Question »

Creative Commons

Related Posters


Etiological diagnostics of cardiomyopathies in the cardiology unit of the HUEH internal medicine department during the period from 8 January 2014 to 14 June 2014
*Axler JEAN PAUL; **Lesly Ed. ARCHER; *Raema Mimrod JEAN; *Gerald VERNELUS; *Rodolph MALEBRANCHE

Medical Student: Move over Stem Cells – Exosomes are Here! What are Exosomes & their role in Regenerative Medicine?
Amartej Singh Deol MD4 & Advisor: Shivinder S. Deol MD

Resident: NONHEALING ULCER THE NEED TO LOOK FURTHER
Briand Bounkeu MD; Ravi Shekarappa MD; La Toya Jackson DO, FAAFP; Chinedu Ivonye MD, FACP; Cristal Kudiwu MD

Striving for Equity in Surgical, Anesthesia, and Obstetric Research in Haiti: A Multi-Partner, International Research Training Collaboration
Dr. Jean Alouidor*, Dr. Frédéric Barau Déjean*, Dr. Louis-Franck Télémaque, Dr. Ronald Eveillard, Dr. Laëlle Mangurat, Dr. Isaac Martineau, Dr. Chartelin Jean Isaac, Dr. Darlène Rochelin Paultre, Carine Réveil Jean-Baptiste, Dr. Lucile Louis Riché, Dr. Jordan Pyda, Rolvix Patterson III, Dr. Blake Alkire, Dr. Eunice Dérivois-Mérisier (*Co-First Authors)

Projektstatus: Entwicklung einer konsensbasierten Therapieempfehlung für die PADOVAN-METHODE® in der Neurorehabilitation
Eisenmeier, Dimitri1; Ostermann, Thomas1; Vogel, Hannah1; Fetz, Katharina1