Posters
« Back
Accelerated Ageing in Depression: A Study of Two Cohorts
EP30253
Poster Title: Accelerated Ageing in Depression: A Study of Two Cohorts
Submitted on 07 Jul 2019
Author(s): Mathew A. Harris, Laura de Nooij, Xueyi Shen, Toni-Kim Clarke, Riccardo Marioni, Simon R. Cox, Emma L. Hawkins, Mark J. Adams, Liana Romaniuk, Stephen M. Lawrie, James H. Cole, Andrew M. McIntosh and Heather C. Whalley
Affiliations: Division of Psychiatry / Department of Psychology, University of Edinburgh; Centre for Neuroimaging Science, King's College London
This poster was presented at OHBM 2019
Poster Views: 761
View poster »


Poster Information
Abstract: Major depressive disorder (MDD) is a severe psychiatric disorder associated with shortened lifespan and comorbidities of advancing age. Accelerated biological ageing may underlie these associations. We used brainageR (a machine learning package) to predict age from brain structure, then used the discrepancy between brain-predicted age and chronological age as an indicator of accelerated brain ageing and poorer brain health. In two cohorts, UK Biobank and STRADL, MDD cases showed slightly higher brain age. Effects were stronger when focusing on MDD cases who were using psychotropic medications, suggesting that these medications contribute to brain ageing acceleration. Alternatively, subjects on medication may represent more severe cases of MDD.
Summary: Depressed individuals had slightly older-appearing brains than controls. Medication was associated with greater brain ageing acceleration.
References: Report abuse »
Questions
Ask the author a question about this poster.
Ask a Question »

Creative Commons

Related Posters


The Ebola Virus: Community Awareness
SAMBASIVARAO YARAGALLA, Navami Guru, Dagbue Sophia, Hernandez Aleyda San, Kamal sepla, Alrashid Zaid Arkan, Daniel Cheong, Abhinaya Murali, Chelsea Dilsuk, Khushal Alete, Savin Peter, Badrinarayana Ajay Maharaj

Fluorescent In Situ Hybridization
Hannah

World on Fire
Emilio Sempris

Public Responsibilities to fight COVID19
Ramesh Vithoba Shinde

ANTIMICROBIAL ACTIVITY OF NEWER DISINFECTANT ON MULTIDRUG RESISTANCE ORGANISMS IN ST.LUCIA
DR. SAMBASIVARAO YARAGALLA, DHRUV PATEL,MEET PATEL, OKUNLOLA OLUWASEMILORE I , CHUKWUEBUNI ONYEBUCHI HANNAH, IJEOMA NWABUOKEI