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Acoustophoretic microfluidic device for high throughput DNA sequencing
Poster Title: Acoustophoretic microfluidic device for high throughput DNA sequencing
Submitted on 29 May 2015
Author(s): V.V Unnikuttan1, H.N Unni 1
Affiliations: Dept. of Biomedical Engineering IIT Hyderabad
This poster was presented at International Conference on Advances in Next Generation Sequencing
Poster Views: 1,888
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Poster Information
Abstract: Modern DNA sequencing technique is a cumbersome, expensive and vast lab process and our aim is the miniaturization of the huge lab process which brought about the inception of the device known as “lab-on-a-chip” (LOC). Acoustophoresis is the ultrasound-induced control of the motion of particles in the microfluidic channel which is rapidly becoming a popular technology in the modern LOC devices.
The factors that affect particle motion in the channel on application of acoustic wave are mainly volume of particle, compressibilities and densities of particle and medium and the acoustic pressure applied which depends on the acceleration of the piezo- crystal. Acoustophoretic transport can be modeled by Continuity equation, Navier-Stokes equation, and Convection – Diffusion equation. The resonant frequency of piezo- crystal corresponding to maximum pressure or acceleration, depends on the piezo- material, size and voltage applied to it. The present study focuses on the optimization of acoustic parameters and simulation of particle transport using COMSOL.
Acoustic standing wave technology combined with micro technology opens up new areas for the development of advanced particle separating microfluidic systems with reasonable throughput and ability to separate particles that helps us to make an automated device for preparing purifying and analyzing DNA samples.
Summary: Multiphysics modelling for acoustic standing wave technology combined with micro-technology which can be used for manipulation and concentration on typical Lab-on-Chip devices for DNA sequencing.References: [1] Chip integrated strategies for acoustic separation and manipulation of cells and particles Thomas Laurell*a Filip Peterssona and Andreas Nilssona , 2007
[2] H. Bruus, Theoretical Microfluidics, Oxford University Press, Oxford, 2008
[3]T. Ikeda,Fundamentals of Piezoelectricity(Oxford University Press, New York, 1996)
[9] Recent advances in particle and droplet manipulation for lab-on-a-chip devices based on surface acoustic waves, Zhuochen Wang and Jiang Zhe, S. A. Ruiz and C. S. Chen,Stem Cells, 2008
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