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Activation of oncogenic PIK3CA induces serrated intestinal cancer
EP32670
Poster Title: Activation of oncogenic PIK3CA induces serrated intestinal cancer
Submitted on 09 Jun 2020
Author(s): Meng Lei¹, Regina Chirst¹, Markus Tschurtschenthaler¹ and Dieter Saur¹
Affiliations: Institute of Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, Klinikum rechts der Isar,Technische Universität München, 81675 München, Germany.
This poster was presented at TranslaTUM, Klinikum rechts der Isar,Technische Universität München, 81675 München, Germany.
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Poster Information
Abstract: Background: Colorectal cancerogenesis is initiated by a stepwise accumulation of genetic alterations. PIK3CA somatic gene mutation is found in
around 20% of colorectal cancer, however, its role in intestinal cancer formation remains largely unclear.
Aim: To dissect the function of oncogenic PIK3CA in intestinal tumorigenesis using genetically defined mouse models.
Materials and Methods: To investigate the role of PIK3CA in intestinal tumorigenesis, our group generated mice with conditional activation of PIK3CAH1047R in intestinal epithelial cells (IECs) using a Cre recombinase that is driven by the IEC-specific promoter Villin (Vil-Cre).
Summary: In this work, we demonstrate that oncogenic PIK3CA induce carcinogenesis in the small, but not large intestine. Regarding the underpinning mechanism behind this, further research needs to be carried out on tumor signaling and microenvironment.References: Eser, Stefan, et al. Cancer cell 23.3 (2013): 406-420.
Rad, Roland, et al. Cancer cell 24.1 (2013): 15-29.
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