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EP38457

Poster Title: Advantages of a Dynamic Polygon for MHC Class I and II Immunopeptides
Submitted on 09 Mar 2022
Author(s): Francesco Pingitore1, Michael Krawitzky1, Josh Elias2, Chris Adams1;
Affiliations: 1Bruker Daltonics, San Jose, CA, USA, 2Chan Zuckerberg Biohub, Stanford - CA
Poster Views: 217
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Poster Information

Abstract: MHC-associated peptides modulate T cell immunity and play a critical role in generating effective anti-tumor immune responses1. Characterization of these peptides helps to generate therapeutic treatments and gain information on T cell mediated biomarkers. These peptides are challenging to characterize due to similar length, sequence conservation and lacking a defined termini when compared to peptides generated upon enzymatic digestion. To overcome these challenges, use of PASEF (Parallel Accumulation and Serial Fragmentation) enables to generate high quality peptide spectra and resolve coeluting and isobaric peptides. Moreover, the capability to easily tailor the mobility space enables preferential detection of groups and sub-groups of relevant peptides.Summary: MHC-associated peptides modulate T cell immunity and play a critical role in generating effective anti-tumor immune responsesReferences: 1) Lill et al.; Proteomics 2017, Volume 17, Issue 1-2: 1770010Report abuse »

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