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Alignment of chromatograms to facilitate visual comparison of data collected at different points in time or with different instruments
EP23991
Poster Title: Alignment of chromatograms to facilitate visual comparison of data collected at different points in time or with different instruments
Submitted on 25 Apr 2016
Author(s): Patrik Petersson1, Annika Sjölander1, Melvin R Euerby2,3, Andrey Vazhentsev4 and Karim Kassam4
Affiliations: 1Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark 2Hichrom Ltd, 1 The Markham Centre, Station Road, Theale, Reading Berkshire, RG7 4PE, England 3Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G40RE 4Advanced Chemistry Development (ACD/Labs), 8 King Street East, Suite 107, Toronto, M5C 1B5, Canada.
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Abstract: Data collection at different time points or with different instruments, e.g., during the stability studies conducted during the development of pharmaceuticals, will differ slightly due to column or mobile phase batch to batch variation. Also differences between instruments will contribute, e.g. column thermostat design, dwell volume, etc. This will result in small shifts in selectivity, retention, signal intensity and shape/level of the baseline. It thereby becomes difficult to visually spot differences between chromatograms. The current study describes the development and evaluation of an algorithm that address this problem.Summary: Data collection at different time points or with different instruments will differ slightly due to column or mobile phase batch to batch variation. This will result in small shifts in selectivity, retention, signal intensity and shape/level of the baseline. It thereby becomes difficult to visually spot differences between chromatograms. References: [1] ACD/ChromWorkbook 2015 (modified alpha version Feb 2015),Advanced Chemistry Development (ACD/Labs), Toronto, Canada, www.acdlabs.comReport abuse »
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