We've updated our Privacy Policy to make it clearer how we use your personal data.
We use cookies to provide you with a better experience, read our Cookie Policy
EP23991
Poster Title: Alignment of chromatograms to facilitate visual comparison of data collected at different points in time or with different instruments
Submitted on 25 Apr 2016
Author(s): Patrik Petersson1, Annika Sjölander1, Melvin R Euerby2,3, Andrey Vazhentsev4 and Karim Kassam4
Affiliations: 1Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark 2Hichrom Ltd, 1 The Markham Centre, Station Road, Theale, Reading Berkshire, RG7 4PE, England 3Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G40RE 4Advanced Chemistry Development (ACD/Labs), 8 King Street East, Suite 107, Toronto, M5C 1B5, Canada.
Poster Views: 1,506
Submitted on 25 Apr 2016
Author(s): Patrik Petersson1, Annika Sjölander1, Melvin R Euerby2,3, Andrey Vazhentsev4 and Karim Kassam4
Affiliations: 1Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark 2Hichrom Ltd, 1 The Markham Centre, Station Road, Theale, Reading Berkshire, RG7 4PE, England 3Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G40RE 4Advanced Chemistry Development (ACD/Labs), 8 King Street East, Suite 107, Toronto, M5C 1B5, Canada.
Poster Views: 1,506
Abstract: Data collection at different time points or with different instruments, e.g., during the stability studies conducted during the development of pharmaceuticals, will differ slightly due to column or mobile phase batch to batch variation. Also differences between instruments will contribute, e.g. column thermostat design, dwell volume, etc. This will result in small shifts in selectivity, retention, signal intensity and shape/level of the baseline. It thereby becomes difficult to visually spot differences between chromatograms. The current study describes the development and evaluation of an algorithm that address this problem.Summary: Data collection at different time points or with different instruments will differ slightly due to column or mobile phase batch to batch variation. This will result in small shifts in selectivity, retention, signal intensity and shape/level of the baseline. It thereby becomes difficult to visually spot differences between chromatograms. References: [1] ACD/ChromWorkbook 2015 (modified alpha version Feb 2015),Advanced Chemistry Development (ACD/Labs), Toronto, Canada, www.acdlabs.com
Ask the author a question about this poster.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Related Posters
Evaluation of Laser Cleaning of Parchment, Wool and Featherwith High Performance Liquid Chromatography and AttenuatedTotal Reflection -Fourier Transform Infrared Spectroscopy
Stamatis C. Boyatzis, Eleni Ioakimoglou, Eleni Tziamourani, Efrosini Karantoni Ekaterini Malea, Stavroula Rapti, Paraskevi Pouli, Athanassia Papanikolaou, Kristalia Melessanaki, Georgios Panagiaris
Dissecting the genomic profile of persistently infecting oncolytic Newcastle disease virus (NDVpi) from cancer RNA-Seq data
Ahmad U1, Chan SC2, Chau DM1, Chia SL5, Abdullah S1,3, Yusoff K5 & Veerakumarasivam A1,4*
Degradation of Artificially Aged Vegetable-Tanned Leather using RP-HPLC and FTIR-ATR
Yadi Hu, Eleni Tziamourani, SC Boyatzis, Jingru Wang, Lvyang Wang, Keyong Tang
Appropriateness of MRCP use in a DGH
A Elawad, B Billimoria
Bleeding Pseudoaneurysm in uncommon locations: interesting cases
Dr Joel James (SHO), Dr Chandni Patel (SpR) & Dr Shirish Prabhudesai (Consultant)