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Ancestry informative eQTLs in prostate tumor tissue: implications for observed cancer disparities
EP27141
Poster Title: Ancestry informative eQTLs in prostate tumor tissue: implications for observed cancer disparities
Submitted on 08 Feb 2018
Author(s): Jordan Creed
Affiliations: Moffitt Cancer Center
This poster was presented at USF Research Day 2018
Poster Views: 388
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Poster Information
Abstract: African-American men (AAM) are 1.6 times more likely to be diagnosed and 2.4 times more likely to die of prostate cancer (PCa) than European-American men (EAM). Most biomarker research is performed utilizing samples from EAM, and, due to a dearth of data in AAM, it is largely unclear to what extent molecular correlates of PCa initiation and outcomes may be race-specific. This project explores genome-wide differences by race in the distribution of expression quantitative trait loci (eQTLs) in PCa tumor tissues, with specific analytic attention given to SNPs that are known to diverge in ancestral populations.
Summary: This project explores genome-wide differences by race through the distribution of expression quantitative trait loci (eQTLs) in PCa tumor tissues, with specific analytic attention given to SNPs that are known to diverge in ancestral populations.
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