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EP38431
Abstract: LC-MS combines the HPLC and MS with an interface which delivers samples in different material states. There are currently five commonly used ionization methods: Inductively Coupled Plasma Ionization(ICP), Electron Impact Ionization(EI), Chemical Ionization(CI), Matrix-Assisted Laser Desorption Ionization(MALD) and Atmospheric Pressure Ionization(API). In drug analysis, LC-MS is widely used in impurity analysis, content determination and drug metabolism studies.Summary: LC-MS has been widely used in many fields, such as food analysis, environmental analysis and pharmaceutical research, because it has many advantages such as high separation ability of chromatog-raphy, high selectivity and high sensitivity of mass spectrometry, and can provide relative molecular weight and structural information.References: Schneider, A., Wessjohann, L. A., Severi, J. A., & Wagner, V. (2012). ‘Comparison of impurity profiles of lipiblock? vs. orlistat using hplc and lc-ms/ms.’ Latin American Journal of Pharmacy, 31(1): 91-96.
Mahadik, M., Bhusari, V., Kulkarni, M., & Dhaneshwar, S. (2009). ‘lc–uv and lc–ms evaluation of stress degradation behaviour of tenatoprazole.’ Journal of Pharmaceutical & Biomedical Analysis, 50(5): 787-793.
Yang, J., Zhao, X., Liu, X., Wang, C., Gao, P., & Wang, J., et al. (2006). ‘High performance liquid chromatography-mass spectrometry for metabonomics: potential biomarkers for acute deterioration of liver function in chronic hepatitis b.’ Journal of Proteome Research, 5(3): 554-561.
https://www.alfachemic.com/testinglab/applicationnote/application-of-lc-ms-in-qualitative-and-quantitative-analysis-of-drugs.html
Mahadik, M., Bhusari, V., Kulkarni, M., & Dhaneshwar, S. (2009). ‘lc–uv and lc–ms evaluation of stress degradation behaviour of tenatoprazole.’ Journal of Pharmaceutical & Biomedical Analysis, 50(5): 787-793.
Yang, J., Zhao, X., Liu, X., Wang, C., Gao, P., & Wang, J., et al. (2006). ‘High performance liquid chromatography-mass spectrometry for metabonomics: potential biomarkers for acute deterioration of liver function in chronic hepatitis b.’ Journal of Proteome Research, 5(3): 554-561.
https://www.alfachemic.com/testinglab/applicationnote/application-of-lc-ms-in-qualitative-and-quantitative-analysis-of-drugs.html
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