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Application review of pseudoUridine and its derivatives
Poster Title: Application review of pseudoUridine and its derivatives
Submitted on 06 Mar 2023
Author(s): BOC Sciences
Poster Views: 64
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Poster Information
Abstract: Pseudouridine is the most abundant RNA modification in cellular RNA. Pseudouridine (abbreviated by the Greek letter psi- Ψ) is an isomer of the nucleoside uridine in which the uracil is attached via a carbon-carbon instead of a nitrogen-carbon glycosidic bond. The C-C bond gives
it more rotational freedom and conformational flexibility. It has an additional hydrogen bond donor at N1.
Summary: Since 1-methylpseudouridine (m1Ψ) modification has been proven successful in COVID-19 mRNA vaccines development, the research of pseudouridine and its derivatives modifications are in full swing not only in the field of mRNA vaccines, but also in the field of mRNA-based cell therapeutics and RNA therapeutics.References: abuse »
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