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Artificial Multi-Gene Expression Systems Design Service for  Natural Compound Formation and Hetero Protein Complexes
Poster Title: Artificial Multi-Gene Expression Systems Design Service for Natural Compound Formation and Hetero Protein Complexes
Submitted on 09 Oct 2014
Author(s): Bernauer, Hubert, Gregor Zipf and Josef Maier
Affiliations: ATG:biosynthetics GmbH, IStLS
This poster was presented at Miptec Basel September 2014
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Abstract: ATG:biosynthetics has developed analytical comparative genomics and constructive in silico solutions for the field of multi-gene construction and multiple-protein expression systems where all orchestral genes
are located on one to a few assembled constructs. We achieve this by intended, constructive biological designs based on experience learned during many customer projects. Constructive molecular biology ap-proaches for creating artificial multi-gene expression systems in order to express natural compounds - in vivo and in vitro - need basic molecular design concepts, synthetic bioinformatics services, vector systems and functionally predictive sequence modulations. Multi-parametric sequence optimization calculations of regulator regions and coding sequences of pathway genes are performed in parallel. Thorough comparative analyses of related genomes allow the extraction of host-specific design rules, which are applied during sequence optimization. Our setups include iterative design of experiments that makes extensive
use of active learning heuristics, in order to speed up the overall pathway optimization processes.
Summary: Drug discovery of natural compounds drug development and drug target analyses as well as bioproduction can benefit from artificial genetic systems and constructions. The direction in which genes are to be developed is written in the genomes. Synthesis oriented genomic analyses of codon bias and tRNA adaption analyses are prerequisites for generating adaptive, highly functional genes. References: Osswald et al. (2012) DOI: 10.1021/sb300080t— www.atg-biosynthetics.deReport abuse »
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