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Association of Nonalcoholic Fatty Liver Disease with Insulin Resistance in Type 2 Diabetes Mellitus – A prospective study
EP26648
Association of Nonalcoholic Fatty Liver Disease with Insulin Resistance in Type 2 Diabetes Mellitus – A prospective study
Submitted on 12 Nov 2017

Jasim Jalal; Shobha P; Nisha N; Shani Basheer; Nelson Joseph
Department of Family Medicine, VPS Lakeshore Hospital, Kochi, Kerala, India
This poster was presented at MUZIRISCON 2017
Poster Views: 454
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Poster Abstract
Background: Association of Nonalcoholic fatty liver disease (NAFLD) with type 2 diabetes mellitus (T2DM) is common.
 
Materials and Methods: Our study population included 100 patients of T2DM. Presence of fatty liver in these patients was determined by abdominal sonography. Insulin Resistance was assessed by Homeostasis Model Assistant - Insulin Resistance (HOMA-IR).
 
Results: The study group (n = 100) was divided into a NAFLD group (n = 55) and a non-NAFLD group (n = 45). The prevalence of NAFLD in our study was 55%. The prevalence of obesity, central obesity was higher in NAFLD group with increased values of HbA1c and triglyceride levels. Insulin Resistance was significantly higher in NAFLD group.

Conclusion: Presence of NAFLD among T2DM patients is significantly associated with Insulin resistance.


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2. Gastaldelli A, Miyazaki Y, Pettiti M, Matsuda M, Mahankali S, Santini E, et al. Metabolic effects of visceral fat accumulation in type 2 diabetes. J Clin Endocrinol Metab 2002; 87:5098‑103.

3. Adams LA, Angulo P. Recent concepts in non‑alcoholic fatty liver disease. Diabet Med 2005; 22:1129‑33.

4. Bayard M, Holt J, Boroughs E. Nonalcoholic fatty liver disease. Am Fam Physician 2006; 73:1961‑8.

5. McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 2004; 8:521‑33.
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