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Automated Rapid Antibody screening with a UHR ESI QTOF Mass Spectrometer and BioPharma Compass
EP38449
Poster Title: Automated Rapid Antibody screening with a UHR ESI QTOF Mass Spectrometer and BioPharma Compass
Submitted on 09 Mar 2022
Author(s): Anjali Alving 1 , Paul Nobrega 2
Affiliations: Bruker Scientific LLC., Billerica, MA Institute for Protein Innovation, Boston, MA
Poster Views: 375
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Poster Information
Abstract: • A comprehensive characterization of therapeutic mAbs is critical. PTMs including oxidation, deamidation, glycosylation may significantly alter the efficacy and safety of the protein drug.
• Regulatory agencies require a full characterization of the biological and chemical heterogeneity of any biological drug product.
• This work focuses on the utility of the maXis II UHR QTOF for rapid screening of mAbs at the intact protein and peptide level for sequence characterization and MAM analysis.
• The automated workflow is implemented using BioPharma Compass software which encompasses data acquisition, processing and reporting using a seamless workflow solution.Summary: This work focuses on the utility of the maXis II UHR QTOF for rapid screening of mAbs at the intact protein and peptide level for sequence characterization and MAM analysis.Report abuse »
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