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Automated Sample Preparation of Whole Blood for Therapeutic Drug Monitoring and Diagnostics by LC-MS using a Commercial Autosampler
EP24167
Automated Sample Preparation of Whole Blood for Therapeutic Drug Monitoring and Diagnostics by LC-MS using a Commercial Autosampler
Submitted on 06 Jun 2016

Christian Berchtold1, Irene Wegner1,Timm Hettich1, Reto Bolliger2, Guenter Boehm2, Goetz Schlotterbeck1
1 University of Applied Sciences and Arts Northwestern Switzerland FHNW, Institute for Chemistry and Bioanalytics , GrĂ¼ndenstrasse 40, 4132 Muttenz; 2 CTC Analytics AG; Industriestrasse 20, CH-4222 Zwingen; Switzerland
This poster was presented at ASMS 2016
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Poster Abstract
Automated sample preparation reduces the costs per sample and avoids sample handling errors. This is especially important in therapeutic drug monitoring or diagnostics based on blood samples. The use of robots is well established in these fields since a long time. Usually expensive
and highly specialized pipetting robots are used for a high number of samples. However, most of these systems are not designed with a direct interface for LC-MS applications.
In this project the parameters necessary to automatically prepare whole blood samples for online LC-MS applications in the field of diagnostics and TDM have been investigated. A strategy and the most important parameters are shown for the optimization of a PAL RTC autosampler
for the preparation of whole blood.

Linder et al. Bioanalysis (2015) 4 (16), 2013-2039
Seger et al. Nature Protocols (2009) 4 (4), 526-534
[Fingerhut et al. Rapid Communications in Mass Spectrometry (2014) 28 (8), 965-973
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