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EP39544
Abstract: A crucial application area for catalysts is pharmaceuticals, especially for the synthesis of chemical APIs and intermediates. Metal catalysis has the potential to greatly improve the sustainability of pharmaceutical products, resulting in shorter synthetic routes and higher efficiencies, and more direct access to single stereoisomeric products. Summary: Transition metal catalysis has become the foundation of modern drug design and manufacture. A wide range of transition metal catalyzed reactions including hydrogenation, cross-coupling, metathesis and various addition and oxidation reactions.References: John D. Hayler. (2019). "A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis," Organometallics 38(1): 36-46.
David M. Barnes. (2002). "Development of a Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes for the Synthesis of Endothelin-A Antagonist ABT-546. Scope, Mechanism, and Further Application to the Synthesis of the Antidepressant Rolipram," Journal of the American Chemical Society 124(44): 13097-13105.
Carl A. Busacca. (2011). "The Growing Impact of Catalysis in the Pharmaceutical Industry," Advanced Synthesis Catalysts 353(11-12): 1825-1864.
https://www.alfachemic.com/catalysts/application/catalysts-for-pharmaceutical.html
David M. Barnes. (2002). "Development of a Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes for the Synthesis of Endothelin-A Antagonist ABT-546. Scope, Mechanism, and Further Application to the Synthesis of the Antidepressant Rolipram," Journal of the American Chemical Society 124(44): 13097-13105.
Carl A. Busacca. (2011). "The Growing Impact of Catalysis in the Pharmaceutical Industry," Advanced Synthesis Catalysts 353(11-12): 1825-1864.
https://www.alfachemic.com/catalysts/application/catalysts-for-pharmaceutical.html
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