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Characterization of the salivary protein repertoire of Covid-19 patients during and after disease
EP38469
Poster Title: Characterization of the salivary protein repertoire of Covid-19 patients during and after disease
Submitted on 09 Mar 2022
Author(s): Ulrike Resch 1 , Goran Mitulović 2
Affiliations: 1 Dept. Vasc . Biol. Thromb . Res., CPP, Medical University of Vienna, Austria ; 2 Bruker Austria, Vienna, Austria
Poster Views: 422
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Poster Information
Abstract: The COVID 19 pandemic impressively demonstrated how progress in technology, world wide data sharing and knowledge exchange within the scientific community impacts global health. The pandemic underscored the need for multiple diagnostic strategies providing information on disease onset, progression, immunity and infection sequelae. Saliva, being a kind of virulence reservoir for the SARS CoV 2 virus, is a remarkable fluid in terms of diagnostic possibilities. Its molecular composition and specifically its proteome contains information about the nutritional, immunological and disease/health status. The possibility of non invasive (self collection facilitates straightforward multiple sampling over time, providing not just a disease “snap shot” but offering the opportunity to monitor disease progression and therapeutic interventions.Summary: This study underscores the importance of considering practical aspects sample preparation, data acquisition and analysis in clinical proteomics based on DIA acquisition strategies. Our preliminary results on saliva “liquid biopsies” might be used for pharmacological targeting of protease activities that impact disease progression and saliva aerosol disease dissemination.References: Report abuse »
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