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Characterizing Small Molecules in Biological Extracts using IntelliXtract Data Processing on High Resolution Accurate Mass Time-of-Flight Data
EP20258
Poster Title: Characterizing Small Molecules in Biological Extracts using IntelliXtract Data Processing on High Resolution Accurate Mass Time-of-Flight Data
Submitted on 19 Dec 2013
Author(s): Margaret Antler, Graham A. McGibbon, Vitaly Lashin, Jeffrey S. Patick and Kevin Siek
Affiliations: ACD Labs
Poster Views: 722
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Poster Information
Abstract: Compounds excreted or secreted by organisms can reveal aspects of their normal metabolism or disease states. Illustrative examples include profiling of plasma to investigate the Zucker rat animal model of obesity/diabetes, and probing of bacterial cultures for siderophores—compounds used to scavenge trace metals.Summary: To detect small molecules in biological extracts, LC/MS performed using high resolution time of flight with accurate mass analysis is a powerful technology. Together with advanced data processing algorithms, accurate mass and relative isotope abundance measurements, molecular formulae can be determined and compounds identified. Report abuse »
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