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CHEMOPREVENTIVE EFFECT OF GREEN TEA AND CURCUMIN IN INDUCED ORAL SQUAMOUS CELL CARCINOMA:  AN EXPERIMENTAL STUDY
EP31305
Poster Title: CHEMOPREVENTIVE EFFECT OF GREEN TEA AND CURCUMIN IN INDUCED ORAL SQUAMOUS CELL CARCINOMA: AN EXPERIMENTAL STUDY
Submitted on 11 Feb 2020
Author(s): Mai M.Saleh1, Zeinab E.Darwish2, Manal I.El Nouaem2, Ghada M.Mourad3, Omneya R. Ramadan4
Affiliations: 1. Lecturer of Oral Pathology, Oral Pathology Department, Faculty of Dentistry, Alexandria University, Egypt 2. Professor of Oral Pathology, Oral Pathology Department, Faculty of Dentistry, Alexandria University, Egypt. 3. Professor of Histology and Cell Biology, Histology and Cell Biology Department, Faculty of Medicine, Alexandria University, Egypt. 4. Assistant Professor of Oral Pathology, Oral Pathology Department, Faculty of Dentistry, Alexandria University, Egypt.
This poster was presented at 2nd annual oral pathology scientific day, Faculty of Dentistry, Cairo University
Poster Views: 219
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Poster Information
Abstract: Introduction: Oral squamous cell carcinoma (OSCC) has the highest mortality rates among all carcinomas and is the most common head and neck cancer. Several natural compounds and micronutrients have been under investigation for their efficacy in head and neck cancer chemoprevention. Green tea contains various cancer preventive catechins that have a role in preventing cancer recurrence in various organs in humans. Curcumin, a natural polyphenol, is one of the most investigated biomolecules from Mother Nature. Curcumin has been shown to exert significant growth inhibitory effect on oral precancerous and carcinoma cell lines, and the effect is synergistic with epigallocatechin gallate, the most abundant polyphenol in tea.
Objectives: To investigate the chemopreventive effect of green tea and curcumin through induction of hamster buccal pouch carcinoma by using an apoptotic marker (AnnexinV).
Material and Methods: Squamous cell carcinoma was chemically induced in fifty Syrian golden hamsters divided into 5 groups (10 each). The first group was used as normal control group. The second group received the carcinogenic agent only. The other three groups received green tea, curcumin and combination of both, respectively.
Results: Normal control group (A) revealed neither pathological nor inflammatory changes in the buccal pouch with 1.72% of the cells underwent apoptosis while the cells of positive control group (B) resulted in 11.57% apoptosis. In the study groups, treatment of the cells with green tea (C), curcumin (D) and both of them (E) resulted in 82.22 %, 78.91%, 96.63% apoptosis respectively.
Conclusion: Green tea and curcumin have a significant chemopreventive effect against oral carcinogenesis and the combination of both agents has a better effect.
Summary: This research aims to investigate the chemopreventive effect of green tea and curcumin through induction of hamster buccal pouch carcinoma by using an apoptotic marker (AnnexinV). References: 1. Mao L. Oral squamous cell carcinoma - progresses from risk assessment to treatment. Chin J Dent Res. 2012; 15: 83-8.
2. Knobloch, T.J.; Uhrig, L.K.; Pearl, D.K.; Casto, B.C.; Warner, B.M.; Clinton, S.K.; et al. Suppression of Proinflammatory and Prosurvival Biomarkers in Oral Cancer Patients Consuming a Black Raspberry Phytochemical-Rich Troche. Cancer Prev. Res. 2016;9:159–171.
3. Shimizu, M.; Fukutomi, Y.; Ninomiya, M.; Nagura, K.; Kato, T.; Araki, H.; etal. Green tea extracts for the prevention of metachronous colorectal adenomas: A pilot study. Cancer Epidemiol. Biomark. Prev. 2008;17:3020–3025.
4. Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci.2009; 30:85–94
5. Ning Li, Xiaoxin Chen, Jie Liao, Guangyu Yang, Su Wang, Youssef Josephson, etal. Inhibition of 7,12-dimethylbenz(a)anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinoge
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