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Combining the Accurate Mass and Time Tag and Ion Mobility for Label-free and Missing Peptide Analysis
EP37623
Poster Title: Combining the Accurate Mass and Time Tag and Ion Mobility for Label-free and Missing Peptide Analysis
Submitted on 02 Sep 2021
Author(s): Robin Park1, Titus Jung 3, Sven Brehmer2, Patrick Garrett3, Vijayaraja Gnanasambandan1, Marc-Antoine Beauvais1, Casimir Bamberger3, Hyunsoo Kim3, Christopher Adams1, Dennis Trede2, John R. Yates, III3, Rohan Thakur1 1Bruker Daltonics Inc., USA 2Bruker Daltonik GmbH, Germany 3Scripps Research, San Diego, USA
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Poster Information
Abstract: •Ion mobility is critical metric to find correct precursor peaks from co-eluting or noisy peaks.
•Accurate Mass, Time Tag and ion mobility library is useful for analyzing large cohort experiments efficiently
Summary: In this study, we applied high throughput 4-D proteomics strategy to the AMT tag by adding the ion mobility dimension (CCS-centric AMT tag), which plays a critical role in clarifying such ambiguities. The timsTOF Pro and timsTOF fleX instruments provide four-dimensional data space called 4DProteomics with CCS values and parallel accumulation serial fragmentation (PASEF) to improve ion utilization efficiency and data acquisition speed.References: Report abuse »
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