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Comparing The Anti-Alzheimer
EP27189
Poster Title: Comparing The Anti-Alzheimer's Activity of Different Types of Coffee
Submitted on 09 Feb 2018
Author(s): Erica Ginsburg, Umer Khan, Phillip Pham, Anmol Kundlas, Simran Gill
Affiliations: University of South Florida
This poster was presented at USF Research Day 2018
Poster Views: 660
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Poster Information
Abstract: Epidemiological data and recent scientific publications
provide support for the neuroprotective effects of coffee
against AD(1). The proposed mechanisms of therapeutic
benefits include inhibition of an enzyme known as alpha
secretase which results in lower levels of Amyloid beta
plaques and increase in a hematopoietic factor known as
GCSF(2). The aim of this study is to find the amount of
coffee and type of coffee which ensures cell survival while
reducing amyloid beta levels. N2APP are neuroblastoma
cells from the APPsw mouse model with mutated genes for
developing Alzheimer’s disease. N2APP cells can be treated
with various drugs and the cytotoxicity of these drugs on
their neurons can be measured using MTT assay. The
survival rate of cells at various concentrations of coffee
treatment can be quantified. 24 hours after drug treatment,
the supernatant was collected, and amyloid beta levels were
measured using ELISA. The data in this study is based on
treatment of N2APP cells with Instant coffee and common
commercial coffee solutions.
Summary: This study found that coffee solutions treated at 5% are toxic to neurons. However, the toxicity reduced significantly at 2.5%. While the toxicity was significantly less allowing for more cells to survive at 2.5%, the levels of toxic amyloid beta 1-42 significantly reduced. This reduction in amyloid beta is associated with improvement in cognitive performance, as the presence of these toxic peptides is one of the characteristics of AD pathophysiology. References: 1. Cao C, Wang L, Lin X, et al. (2011) Caffeine synergizes with another coffee component to increase plasma GCSF: Linkage to
cognitive benefits in Alzheimer's mice. J Alzheimers Dis 25: 323-335.
2. Khan UN, Cao C (2018) Coffee Consumption Provides Therapeutic Benefits against AD through Increasing Plasma GCSF Levels
andImproving Cognitive Performance. J Clin Neurol Neurosurg 1: 103.
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