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Comparison of Smoker’s and Non-Smoker’s Urine Using Comprehensive Two-Dimensional Gas Chromatography High Performance Time-of-Flight Mass Spectrometry
EP27349
Poster Title: Comparison of Smoker’s and Non-Smoker’s Urine Using Comprehensive Two-Dimensional Gas Chromatography High Performance Time-of-Flight Mass Spectrometry
Submitted on 07 Mar 2018
Author(s): David E. Alonso and Joseph E. Binkley
Affiliations: LECO Corporation
This poster was presented at Pittcon 2018
Poster Views: 758
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Poster Information
Abstract: Urine is a favored biofluid for diagnostic testing (Urinalysis) because it is non-invasive and large volumes are easily obtained. In addition, urine is relatively free from interfering proteins and lipids, and it tends to “hold” high concentrations of drugs and metabolites over extended periods of time. Modern, routine clinical tests include the determination of specific gravity, measurement of glucose, nitrates, etc.

In this study, a novel analytical approach was utilized for the effective characterization of compounds in two standard reference materials, NIST smoker’s and non-smoker’s urine.

Objectives
Implement the use of enhanced, comprehensive two-dimensional gas chromatography (GCxGC) for the separation of compounds in urine
Use a benchtop, high-performance time-of-flight mass spectrometer and powerful processing software to quickly and confidently identify compounds in urine
Use software tools to compare smoker’s and non-smoker’s urine
Summary: The Pegasus BT 4D facilitates fast and confident compound identification through enhanced two-dimensional chromatographic resolution and high performance TOFMS.
Robust compound identification was obtained through spectral similarity searches of large, well-established databases, mass D calculations and retention index filtering.
Comprehensive data can be processed via non-targeted Peak Find or rapid Target Analyte Finding.
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