« Back
Comprehensive, Non-Target Characterization of Environmental Exposome Samples Using GCxGC and High Resolution Time-of-Flight Mass Spectrometry
Poster Title: Comprehensive, Non-Target Characterization of Environmental Exposome Samples Using GCxGC and High Resolution Time-of-Flight Mass Spectrometry
Submitted on 21 Jun 2018
Author(s): Todd Richards, Joe Binkley, and Lorne Fell
Affiliations: LECO Corporation
This poster was presented at ASMS
Poster Views: 341
View poster »

Poster Information
Abstract: Historically, targeted analysis has been used to evaluate complex environmental samples. This
constrained testing often misses emerging or unexpected compounds. Recent improvements in chromatographic separation, detection, and processing allow for evaluation of these samples using nontargeted techniques. Further, the EPA is conducting a multiple system evaluation for non-targeted analysis methods in samples designed to mimic the exposome. The project contains two phases, first a blinded study of complex mixtures is evaluated. Subsequently in phase two, the individual standard component lists are revealed and results revised as necessary. Each standard mixture contains between 100-400 spiked analytes with potential contaminants, degradants, and reaction products. This presentation describes the logic used for identification of unknowns, the results, and the lessons learned from the process.
• Multiplexing mass analyzer increases sensitivity 10X
• GC×GC dramatically improves chromatographic resolution and peak detection
• Industry leading deconvolution & non-target detection
• High Resolution Accurate Mass (HRAM) data allows for molecular and fragment ions formula calculations and verification
• ChromaTOF® brand software – A single software for total hardware control and data processing
Summary: GC×GC dramatically improved chromatographic peak resolution leading to superior deconvolution and identification for non-target analysis of complex samples. LECO's industry-leading High Resolution Deconvolution® (HRD®) software feature provides clean mass spectra with unsurpassed spectral fidelity for library searching. Increasing the coverage of existing GC-MS libraries would speed up non-target investigations and improve identification quality.Report abuse »
Ask the author a question about this poster.
Ask a Question »

Creative Commons

Related Posters

Multiplex miRNA Profiling for Biomarker Discovery and Verification Studies Using the FirePlex® Platform
M. Tackett, B. Heinrich, I. Diwan, G. Tejada, C. Rafferty, E. Atabakhsh, and D. Pregibon

PEAKS™ Software for the processing of timsTOF Pro PASEF data: identification and label-free quantitation
Markus Lubeck(1), Heiner Koch(1), Scarlet Beck(1), Paul Savage(2), Oliver Raether(1), Pierre-Olivier Schmit(2) Paul Shan (3) and Gary Kruppa (4)

Salamanca,G. G. , Osorio, T. M.; Scriche, R. I.

MALDI Imaging Mass Spectrometry for the study of cardiovascular pathology
Takashi Nirasawa1, Megumi Terada2,3, Hiroko Namba2, Nobuto Kakuda2, Patrick Bruneval3, Hatsue Ishibashi-Ueda4 and Masaya Ikegawa1

Distinct deposition of amyloid-bspecies in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry
Nobuto Kakuda1, Tomohiro Miyasaka1, Takashi Nirasawa2, Shigeo Murayama3, Yasuo Ihara1 and Masaya Ikegawa1