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Comprehensive, Non-Target Characterization of Environmental Exposome Samples Using GCxGC and High Resolution Time-of-Flight Mass Spectrometry
Poster Title: Comprehensive, Non-Target Characterization of Environmental Exposome Samples Using GCxGC and High Resolution Time-of-Flight Mass Spectrometry
Submitted on 21 Jun 2018
Author(s): Todd Richards, Joe Binkley, and Lorne Fell
Affiliations: LECO Corporation
This poster was presented at ASMS
Poster Views: 468
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Poster Information
Abstract: Historically, targeted analysis has been used to evaluate complex environmental samples. This
constrained testing often misses emerging or unexpected compounds. Recent improvements in chromatographic separation, detection, and processing allow for evaluation of these samples using nontargeted techniques. Further, the EPA is conducting a multiple system evaluation for non-targeted analysis methods in samples designed to mimic the exposome. The project contains two phases, first a blinded study of complex mixtures is evaluated. Subsequently in phase two, the individual standard component lists are revealed and results revised as necessary. Each standard mixture contains between 100-400 spiked analytes with potential contaminants, degradants, and reaction products. This presentation describes the logic used for identification of unknowns, the results, and the lessons learned from the process.
• Multiplexing mass analyzer increases sensitivity 10X
• GC×GC dramatically improves chromatographic resolution and peak detection
• Industry leading deconvolution & non-target detection
• High Resolution Accurate Mass (HRAM) data allows for molecular and fragment ions formula calculations and verification
• ChromaTOF® brand software – A single software for total hardware control and data processing
Summary: GC×GC dramatically improved chromatographic peak resolution leading to superior deconvolution and identification for non-target analysis of complex samples. LECO's industry-leading High Resolution Deconvolution® (HRD®) software feature provides clean mass spectra with unsurpassed spectral fidelity for library searching. Increasing the coverage of existing GC-MS libraries would speed up non-target investigations and improve identification quality.Report abuse »
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