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Physician/Fellow: Consider Improving Cognitive Impairment with the Revival of Neurosteroid Supplementation
EP30799
Poster Title: Physician/Fellow: Consider Improving Cognitive Impairment with the Revival of Neurosteroid Supplementation
Submitted on 15 Oct 2019
Author(s): Sarah N Choo-Yick, MD;Florence T Baralatei, MD
Affiliations: Navicent Health / Mercer University Department of Family Medicine
Poster Views: 96
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Poster Information
Abstract: Cognitive impairment affects more than 16 million Americans [1]. A person with cognitive impairment has trouble remembering new things, concentrating, or making decisions that impact everyday life. Their symptoms can be mild to severe and results in the inability to live independently. The Center for Disease and Control issued a ‘Call to Action’ in 2009 focused on therapeutic models for cognitive impairment [1]. A decade has passed and there remain limited advancements in scientific research.

Currently, there is no cure for cognitive impairment and some forms of this impairment may be related to reversible health causes. A less studied reversible cause is pregnenolone deficiency. Pregnenolone is an excitatory neurosteroid, designated a “parent hormone”, that gives rise to important neurosteroids that affect memory, learning, and much more [2]. Testing for pregnenolone level in a laboratory blood test is simple and cost-effective. If the pregnenolone level is low, a supplementation trial may benefit those diagnosed with cognitive impairment [3]. Today we hope you would give consideration of this therapy and we hope to encourage you to embrace a more comprehensive workup for patients presenting with cognitive impairment.
Summary: Cognitive impairment affects more than 16 million Americans[ 1]
.
Currently, there is no cure for cognitive impairment.

A less studied reversible cause of cognitive impairment is pregnenolone deficiency [3].

Testing for pregnenolone level in a blood test is simple and cost effective.

If the pregnenolone level is low, a supplementation trial may benefit those diagnosed with cognitive impairment [3].

References: 1. Center for Disease and Control. (2011, February). Cognitive Impairment: A Call For Action, Now! Retrieved from https://cdc.gov/aging/pdf/cognitive_impairment/cogimp_policy_final.pdf
2. Enhancing Cognitive Function with Pregnenolone. (2007, November). Retrieved from https://www.lifeextension.com/magazine/2007/11/report_pregnenolone
3. Dastgheib M, Dehpour AR, Heidari M, Moezi L. The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats. Neuroscience 2015; 306:1–9.
4. Scudder C, Kenny P, and Niessen S. Treatment of canine and feline hyperadrenocorticism: trilostane and the alternatives. Comparison Animal 2015. 20:230-238.
5. Sahelian, R. (1997. Pregnenolone: Nature’s Fell Good Hormone. Cornell University: Avery Publishing Group.
6. Pregnenolone. (2018). Retrieved from https://www.webmd.com/vitamins/ai/ingredientmono-98/pregnenolone.
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