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Correlation between tissue expression of  miRNA137 and CD8 in oral lichen planus
Poster Title: Correlation between tissue expression of miRNA137 and CD8 in oral lichen planus
Submitted on 18 Feb 2019
Author(s): Sanaa aghbari, olfat shaker, shaimaa Omar, and el Rahman, atria attia
Affiliations: Oral medicine, faculty of dentistry,Aden university, faculty of medicine ain shams university, faculty of medicine, Cairo university, faculty of dentistry, Cairo university, medicine, Azhar university
This poster was presented at oral & maxillofacial pathology, faculty of dentistry, Cairo university
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Abstract: Correlation between tissue expression of microRNA137 and CD8 in oral lichen planus.

Sana maher hasan aghbari, Shaimaa omar zayed, Abdelrahman Ibrahim aboushouk, Olfat gamil shaker, Shahira EL ashiry, & Attia Attia
Clinical oral investigations, 1:5, October 2017
Objectives: Oral lichen planus (OLP) is a chronic, inflammatory condition, classified by the World Health Organization as a premalignant lesion. We performed this study to evaluate the correlation between microRNA-137 (miR-137) and CD8 oral tissue expression in OLP patients. Materials and methods: Twenty OLP patients [classified into three groups: (a) papular, reticular, or plaque; (b) atrophic; and (c) erosive] and 20 healthy controls were subjected to biopsy of the oral mucosa. To evaluate CD8 tissue expression, we performed immune-histochemical examination, followed by immunostaining and computerized quantification. The expression of miR-137 was evaluated using real-time quantitative PCR. We used SPSS software (version15forwindows) to perform the statistical analysis. Results Our analysis showed an increased tissue expression of CD8 (p < 0.01) and reduced expression of miR-137 (p < 0.001) in OLP patients, compared to the control group. Moreover, there was a statistically significant difference (p = 0.001) between OLP subgroups in terms of CD8 tissue expression [highest in erosive OLP and lowest in popular /reticular/plaque OLP]. However, these subgroups showed no significant difference (p = 0.168) in terms of miR-137expression. A reverse correlation (p < 0.05) between tissue expression of miR-137 and CD8 was noted with a varying correlation coefficient in different OLP subgroups (-0.250 in erosive OLP, -0.491 in atrophic OLP and -0.616 in popular / reticular/plaque OLP). Conclusions: Our findings indicate reduced expression of miR-137 and a reverse correlation between tissue expression of miR-137 and CD8 in the oral mucosa of OLP patients. Potential of miR-137 as OLP disease biomarker. Clinical relevance Future studies should investigate the therapeutic potential of miR-137 overexpression in OLP patients.
Keywords CD8 .miR-137. Malignant transformation .Oral lichen planus
Summary: Statistical significant CD8 expression in OLP patient in comparison to normal oral mucosa. A negative correlation between CD8 expression and miRNA in OLP diseaseReferences: Clinical oral investigation journal , 1:5, October 2017Report abuse »
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