Abstract: This prospective study involved 38 neonate subjects (18 girls/20 boys) for admission in the intensive neonatal care unit, from March 2017 t0 June 2018. Neonatal neurological abnormalities (NA) is a condition that causes significant morbidity and mortality to the infant. The study was planned to assess the role of MRI and (TCUS) in the early identification of cerebral injuries in NA. US findings and MRI who were examined because of problems related to the respiratory distress(35%), early-onset sepsis(18%), premature(13%), hypoxic-ischemic encephalopathy(6%), hydrocephalus(6%), convulsion(3%), late-onset sepsis (3%),meningitis(3%), multiple congenital anomalies syndrome(2%) . The subjects were 2 days to 24 months old. The neonates and infants were (TCUS) examined as the first tool at least coronal and sagittal US, followed by MRI. Results were recorded and diagnosis differential diagnosis was discussedSummary: TCUS is promising and helping, an effective screening tool in detecting the etiology of high-risk neurological abnormalities in suspected cases, It gives information about immediate and long term prognosis, TCUS is fast and bedside; i.We recommend that TCUS should be done first to all critically ill neonates admitted at NICU as screening and should be followed by MRI, References: D.M. Ferriero Neonatal brain injury N Engl J Med, 351 (2004), pp. 1985-1995, H.B. Sarnat, M.S. Sarnat Arch Neurol, 33 (10) (1976), pp. 696-705 Executive summary: Neonatal encephalopathy and neurologic outcome, second edition. Report of the American College of Obstetricians and Gynecologists’ Task Force on Neonatal Encephalopathy. Obstet Gynecol 2014; 123: 8a96., , J.J. Kurinczuk, M. White-Koning, N. BadawiEpidemiology of neonatal encephalopathy and hypoxic–ischaemic encephalopathy Early Hum Dev, 86 (6) (2010 Jun), pp. 329-338, H.B. Sarnat, M.S. Sarnat Arch Neurol, 33 (10) (1976), pp. 696-705, M. Jonsson, J. Ågren, S. Nordén-Lindeberg, et al.Neonatal encephalopathy and the association to asphyxia in labor Am J Obstet Gynecol, 2011 (6) (2014 Dec), pp. 667-Curr Opin Neurol, 18 (2005), pp. 111-116, , F. Triulzi, C. Baldoli, A. Righini Neonatal hypoxic–ischemic encephalopathy, P.T. Donati, R. Rossis Abiancheri (Eds.), Pediatric neuroradiology (4th ed.), Springer, Germany (2005) p. 239–62,
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