We've updated our Privacy Policy to make it clearer how we use your personal data.
We use cookies to provide you with a better experience, read our Cookie Policy

EP38925
Abstract: Because the cyclodextrin cavity is a hydrophobic region, the non-polar lipid-soluble drug is easy to enter and is included, and the formed inclusion complex is less soluble: polar The drug can be embedded in the hydrophilic region of the cavity opening. The formed inclusion complex has high solubility. Hydrophobic drugs are easier to be included, and non-dissociated drugs are easier to be included than dissociated drugs. Self-associative drugs often disassociate first and then embed into cyclodextrin cavities.Summary: After the poorly soluble drug forms an inclusion complex with β-CD, the drug molecule is contained in the β-CD molecule cavity, which has a high degree of dispersion. Or the powdering of liquid drugs increases the solubility of insoluble drugs and improves the bioavailability of drugs.References: https://www.formulationbio.com/cyclodextrin-beta-cd-inclusion-complex-services.html
Ask the author a question about this poster.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Related Posters
Encapsulation Techniques
Helen
Make Phospholipid Complex
Helen
PBPK/RO modeling of anti-PDL1 antibodies
Antonina Nikitich, Oleg Demin Jr
Development of QSP model of COVID-19 based on Immune Response Template
Veronika Musatova, Oleg Demin, Maria Kupriyanova, Anna Viktorenko
Active Pharmaceutical Ingredient Analysis
Tylor