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Development of a nucleic acid-based amplification test as point-of-care rapid test detecting sexually-transmitted diseases for home-care
EP23523
Development of a nucleic acid-based amplification test as point-of-care rapid test detecting sexually-transmitted diseases for home-care
Submitted on 13 Oct 2015

Vicky Tröger, Anja Scherber, Dirk Kuhlmeier, Indrek Tulp, Marko Lehes, Steffen Howitz, Toni Bohatzsch, Tamas Pardy
Fraunhofer Institute of Cell Therapy and Immunology Leipzig, Nanotechnology Unit, D-04103 Leipzig; University of Leipzig, Institute of Analytical Chemistry, Working Group Prof. Belder, D-04103 Leipzig; SelfD Technologie GmbH, D-04103 Leipzig; Gesim – Gesellschaft für Silizium-Mikrosysteme mbH, D-01454 Großerkmannsdorf
This poster was presented at Point-of-Care Diagnostics & Global Health World Congress Agenda, San Diego
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Poster Abstract
In Europe, 350.000 new sexual transmitted infections (STI) caused by Chlamydia types have been registered in 2009 [1]. Approximately 70 % of infections with Chlamydia trachomatis run an asymptomatic course and therefore remain undetected. This can result in severe complications such as chronic diseases, infertility, complications in pregnancy and cancer [2, 3]. Current detection systems commercially available are based on serological methods. However, existing detection strategies have a number of disadvantages including the high market price, delayed diagnostics in the course of infection, false-negative results. Therefore a new, innovative detection system for home-care devices is a rising demand.
We present a microfluidic test system which connects two methods with each other. It combines a high specific isothermal nucleic acid amplification technology with a detection on a simple lateral flow strip.
The microfluidic chip is completed with a non-instrumented mirco-heating solution by using chemical exothermal reactions. As a whole, this nucleic quick test cartridge for Chlamydia trachomatis screening is a promising tool in home-care diagnosis.


[1] World Health Organization: Global incidence and prevalence of selected curable sexually transmitted infections – 2009. WHO 2012.
[2] European Centre for Disease Prevention and Control: Sexually transmitted infections in Europe, 1990-2009. Stockholm: ECDC, 2011.
[3] World Health Organization: Sexually Transmitted Infections (STIs) as a Public Health Issue, Fact Sheet 2004.
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