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Development of a nucleic acid-based amplification test as point-of-care rapid test detecting sexually-transmitted diseases for home-care
EP23523
Poster Title: Development of a nucleic acid-based amplification test as point-of-care rapid test detecting sexually-transmitted diseases for home-care
Submitted on 13 Oct 2015
Author(s): Vicky Tröger, Anja Scherber, Dirk Kuhlmeier, Indrek Tulp, Marko Lehes, Steffen Howitz, Toni Bohatzsch, Tamas Pardy
Affiliations: Fraunhofer Institute of Cell Therapy and Immunology Leipzig, Nanotechnology Unit, D-04103 Leipzig; University of Leipzig, Institute of Analytical Chemistry, Working Group Prof. Belder, D-04103 Leipzig; SelfD Technologie GmbH, D-04103 Leipzig; Gesim – Gesellschaft für Silizium-Mikrosysteme mbH, D-01454 Großerkmannsdorf
This poster was presented at Point-of-Care Diagnostics & Global Health World Congress Agenda, San Diego
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Abstract: In Europe, 350.000 new sexual transmitted infections (STI) caused by Chlamydia types have been registered in 2009 [1]. Approximately 70 % of infections with Chlamydia trachomatis run an asymptomatic course and therefore remain undetected. This can result in severe complications such as chronic diseases, infertility, complications in pregnancy and cancer [2, 3]. Current detection systems commercially available are based on serological methods. However, existing detection strategies have a number of disadvantages including the high market price, delayed diagnostics in the course of infection, false-negative results. Therefore a new, innovative detection system for home-care devices is a rising demand.
We present a microfluidic test system which connects two methods with each other. It combines a high specific isothermal nucleic acid amplification technology with a detection on a simple lateral flow strip.
The microfluidic chip is completed with a non-instrumented mirco-heating solution by using chemical exothermal reactions. As a whole, this nucleic quick test cartridge for Chlamydia trachomatis screening is a promising tool in home-care diagnosis.
Summary: The main problem of early diagnosis of STI is the lack of suitable systems. Therefore a quick home test is needed. In this poster, a microfluidic cartridge combining an isothermal amplification with detection on a lateral flow strip is presented. References: [1] World Health Organization: Global incidence and prevalence of selected curable sexually transmitted infections – 2009. WHO 2012.
[2] European Centre for Disease Prevention and Control: Sexually transmitted infections in Europe, 1990-2009. Stockholm: ECDC, 2011.
[3] World Health Organization: Sexually Transmitted Infections (STIs) as a Public Health Issue, Fact Sheet 2004.
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