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Differences in the Functional BNA™ of Concussed Male and Female Athletes
EP23844
Poster Title: Differences in the Functional BNA™ of Concussed Male and Female Athletes
Submitted on 26 Feb 2016
Author(s): Boaz Sadeh, Michal Weiss, Hadas Or-Ly, Amit Reches, Amir Geva
Affiliations: ElMindA
This poster was presented at Pink Concussions International Summit on Female Concussion and TBI
Poster Views: 1,147
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Poster Information
Abstract: BACKGROUND. The current clinical diagnosis and management of patients suffering from sports-related concussion (SRC) is largely dependent on subjectively reported symptoms and non-specific clinical examinations. Furthermore, symptom scoring and criteria do not differ for males and females despite increasing evidence of sex-based differences. Our group has developed and validated an electrophysiological (EEG) based tool named Brain Network Activation (BNA), designated to be an aid tool for the assessment of brain function in the management of concussed athletes.

OBJECTIVE. The objective of this study is to explore differences between sexes in the functional cortical network response to concussion, as well as in the rehabilitation process, using the BNA technology. We also report a representative case study to exemplify the clinical utility of BNA for female athletes (figure 1).

METHODS. In the BNA technique a Reference Brain Network Model (RBNM) is constructed from an independent group of healthy controls and serves as a biomarker. Individual’s BNA scores are then calculated relative to this reference functional biomarker. In the current study, concussed patients in the age range of 16-25 y/o and age-matched controls were evaluated at 4 time-points with symptom questionnaires and with the BNA. Sex-based differences were tested by evaluating the BNA scores and their progression for males and females apart.

RESULTS. Concussed subjects exhibited a significant decrease in BNA scores immediately following a concussion within both sexes (p<0.01), as well as notable changes in functional network activity across evaluation sessions, relatively to the healthy controls. Differences between the sexes were also found. In particular, females and males differed in their BNA scores across all visits collapsed, both for healthy controls and concussed patients (p<0.01 for both). The sensitivity of the RBNM network, which is composed of more men than women, was found to be different between sexes (figure 2).

CONCLUSION. In the objective assessment of functional brain network changes following SRC, males and females showed notable differences, despite the fact that both populations were scored against the same normative reference brain activation network model. These results strongly suggest the need for sex-based biomarkers and assessment criteria. The BNA technology can bridge this gap by creating sex-based normative network biomarkers, and setting appropriate criteria.
Summary: In the objective assessment of functional brain network changes following SRC, males and females showed notable differences, despite the fact that both populations were scored against the same normative reference brain activation network model. These results strongly suggest the need for sex-based biomarkers and assessment criteria. The BNA technology can bridge this gap by creating sex-based normative network biomarkers, and setting appropriate criteria.Report abuse »
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