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Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction and Neuroprotection in the Elderly
EP27469
Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction and Neuroprotection in the Elderly
Submitted on 17 Apr 2018

Brittany Clark
Nova Southeastern University - Fort Lauderdale
This poster was presented at American Academy of Anesthesiologist Assistants Annual Conference
Poster Views: 360
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Poster Abstract
Postoperative cognitive dysfunction (POCD) is a complication that has a reported incidence of 7% to 71% at 7-8 postoperative days, and 6% to 56% at 42-84 days [5] in elderly patients and predisposes adverse outcomes.
Recently, dexmedetomidine, a highly selective alpha-adrenergic receptor agonist, has been shown to suppress the inflammatory response perioperatively and prevent cortical apoptosis. Evidence has demonstrated that the use of intravenous dexmedetomidine has decreased the incidence of postoperative cognitive dysfunction and improved outcomes following surgery in geriatrics. The mechanism of neuroprotection through the use of dexmedetomidine, may ameliorate cognitive dysfunction in elderly patients who have undergone general anesthesia.


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4. Qian, X., Zhang, W., Liu, M., Zhou, Y., Zhang, J., Han, L., Peng, Y., Jiang, J., Wang, Q. (2015). Dexmedetomidine improves early postoperative cognitive dysfunction in aged mi
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