« Back
Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction and Neuroprotection in the Elderly
Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction and Neuroprotection in the Elderly
Submitted on 17 Apr 2018

Brittany Clark
Nova Southeastern University - Fort Lauderdale
This poster was presented at American Academy of Anesthesiologist Assistants Annual Conference
Poster Views: 360
View poster »
Poster Abstract
Postoperative cognitive dysfunction (POCD) is a complication that has a reported incidence of 7% to 71% at 7-8 postoperative days, and 6% to 56% at 42-84 days [5] in elderly patients and predisposes adverse outcomes.
Recently, dexmedetomidine, a highly selective alpha-adrenergic receptor agonist, has been shown to suppress the inflammatory response perioperatively and prevent cortical apoptosis. Evidence has demonstrated that the use of intravenous dexmedetomidine has decreased the incidence of postoperative cognitive dysfunction and improved outcomes following surgery in geriatrics. The mechanism of neuroprotection through the use of dexmedetomidine, may ameliorate cognitive dysfunction in elderly patients who have undergone general anesthesia.

1. Chen, J., Yan, J., & Han, X. (2012). Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients. Experimental and Therapeutic Medicine,5(2),
489-494. doi:10.3892/etm.2012.811

2. Chen, W., Liu, B., Zhang, F., Xue, P., Cui, R., & Lei, W. (2015). The effects of dexmedetomidine on post-operative cognitive dysfunction and inflammatory factors in senile patients. International Journal of Clinical and Experimental Medicine,8(3), 4601-4605. PMID:PMC4443226

3. Li, Y., He, R., Chen, S., & Qu, Y. (2015). Effect of dexmedetomidine on early postoperative cognitive dysfunction and peri-operative inflammation in elderly patients undergoing laparoscopic cholecystectomy. Experimental and Therapeutic Medicine,10(5), 1635-1642. doi:10.3892/etm.2015.2726

4. Qian, X., Zhang, W., Liu, M., Zhou, Y., Zhang, J., Han, L., Peng, Y., Jiang, J., Wang, Q. (2015). Dexmedetomidine improves early postoperative cognitive dysfunction in aged mi
Report abuse »
Ask the author a question about this poster.
Ask a Question »

Creative Commons