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Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction and Neuroprotection in the Elderly
EP27469
Poster Title: Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction and Neuroprotection in the Elderly
Submitted on 17 Apr 2018
Author(s): Brittany Clark
Affiliations: Nova Southeastern University - Fort Lauderdale
This poster was presented at American Academy of Anesthesiologist Assistants Annual Conference
Poster Views: 461
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Poster Information
Abstract: Postoperative cognitive dysfunction (POCD) is a complication that has a reported incidence of 7% to 71% at 7-8 postoperative days, and 6% to 56% at 42-84 days [5] in elderly patients and predisposes adverse outcomes.
Recently, dexmedetomidine, a highly selective alpha-adrenergic receptor agonist, has been shown to suppress the inflammatory response perioperatively and prevent cortical apoptosis. Evidence has demonstrated that the use of intravenous dexmedetomidine has decreased the incidence of postoperative cognitive dysfunction and improved outcomes following surgery in geriatrics. The mechanism of neuroprotection through the use of dexmedetomidine, may ameliorate cognitive dysfunction in elderly patients who have undergone general anesthesia.
Summary: Dexmedetomidine demonstrated neuroprotection by suppressing the release of proinflammatory factors and neuronal apoptosis. Conflicting results from human and animal studies on the mechanism of neuroprotection with the use of dexmedetomidine warrant further investigation into how this drug regulates proinflammatory factors. Perioperative intravenous administration of dexmedetomidine showed a decreased incidence of POCD in aged patients undergoing general anesthesia.References: 1. Chen, J., Yan, J., & Han, X. (2012). Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients. Experimental and Therapeutic Medicine,5(2),
489-494. doi:10.3892/etm.2012.811

2. Chen, W., Liu, B., Zhang, F., Xue, P., Cui, R., & Lei, W. (2015). The effects of dexmedetomidine on post-operative cognitive dysfunction and inflammatory factors in senile patients. International Journal of Clinical and Experimental Medicine,8(3), 4601-4605. PMID:PMC4443226

3. Li, Y., He, R., Chen, S., & Qu, Y. (2015). Effect of dexmedetomidine on early postoperative cognitive dysfunction and peri-operative inflammation in elderly patients undergoing laparoscopic cholecystectomy. Experimental and Therapeutic Medicine,10(5), 1635-1642. doi:10.3892/etm.2015.2726

4. Qian, X., Zhang, W., Liu, M., Zhou, Y., Zhang, J., Han, L., Peng, Y., Jiang, J., Wang, Q. (2015). Dexmedetomidine improves early postoperative cognitive dysfunction in aged mi
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