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Electrophysiological and cardiotoxicological characterization of human iPSC-derived cardiomyocytes (hiPSC-CMs) in 3D microtissues and 2D monolayers
EP25632
Poster Title: Electrophysiological and cardiotoxicological characterization of human iPSC-derived cardiomyocytes (hiPSC-CMs) in 3D microtissues and 2D monolayers
Submitted on 14 Mar 2017
Author(s): Hortigon-Vinagre, Maria P. 1,2 ; Zamora, Victor1,2 ; Mamta Chabria3 ; Liudmila Polonchuk3 ; Bucerius, Roman4; Burton, Francis. L.1,2 ; Smith, Godfrey L.1,2
Affiliations: 1. Clyde Biosciences, Ltd., Biocity Scotland, Bo’Ness Rd., ML1 5UH Newhouse (UK) 2. Institute of Cardiovascular and Medical Sciences, University of Glasgow, G12 8QQ, Glasgow (UK) 3. Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070, Basel, Switzerland 4. Axiogenesis AG, Cologne, Germany
This poster was presented at Stem Cells in Drug Discovery
Poster Views: 1,173
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Poster Information
Abstract: Adult myocardium operates as a 3D syncytium of cardiomyocytes yet cultures of human induced pluripotent cell derived cardiomyocytes (hiPSC-CMs) are frequently used in a 2D format. However, 3D microtissues
of hiPSC-CMs may present a more physiological model for drug screening, but the format of culture may affect function. This study compared the excitation-contraction coupling process of commercially
derived hiPSC-CMs (Cor4U®, Axiogenesis AG) in 3D micro-tissues and 2D monolayers.
Summary: This study compared the excitation-contraction coupling process of commercially derived hiPSC-CMs (Cor4U®, Axiogenesis AG) in 3D
micro-tissues and 2D monolayers.
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