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Elucidation of metabolic changes in HFD ApoE model by SP6 peptide: A flow injection analysis MRMS study
EP38435
Poster Title: Elucidation of metabolic changes in HFD ApoE model by SP6 peptide: A flow injection analysis MRMS study
Submitted on 09 Mar 2022
Author(s): Eduardo Sommella, 1 Fabrizio Merciai, 1 Albino Carrizzo, 2 Carmine Vecchione, 2 Pietro Campiglia, 1 Heiko Neuweger 3
Affiliations: 1 University of Salerno, Department of Pharmacy, Fisciano (SA), Italy 2 University of Salerno, Department of Medicine and Surgery, Baronissi (SA), Italy 3 Bruker Daltonics GmbH & Co. KG., Bremen, Germany
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Abstract: Metabolic disorders, such as hypertension and dyslipidemia, are comorbid pathologic conditions often found in combination and characterized by a deep connection of altered molecular pathways. The employment of natural compounds in combination to pharmacological treatment can be an attractive option as preventive therapy. Natural peptides are among the most employed compounds. In this regard, a novel antihypertensive decamericpeptide has been recently characterized from the gastro intestinaldigest of Spirulina platensis microalgae [1]. To understand the molecular pathways that are influenced by bioactive compounds, metabolomics has emerged as a leading approach. High resolution mass spectrometry (HRMS) is the workhorse for metabolomics applications, and MRMS due to its high mass accuracy and resolution, facilitates phenotyping studies. In this regard, the objective of this work was to investigate the effect of the SP6 peptide in a mice model of atherosclerosis (high fat diet ApoE–/–) and evaluate the altered molecular pathways by a FIA-MRMS approach, termed MRMS aXelerate®. Results showed evidence of a distinct modulation of key molecular analytes involved in the disease development and open the way to further large-scale studies.
Summary: To understand the molecular pathways that are influenced by bioactive compounds, metabolomics has emerged as a leading approach. High resolution mass spectrometry (HRMS) is the workhorse for metabolomics applications, and MRMS due to its high mass accuracy and resolution, facilitates phenotyping studies.References: [1] Carrizzo et al. (2019), https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.11801
[2] Matyash et al. (2008), https://dx.doi.org/10.1194%2Fjlr.D700041 JLR200
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