Abstract: In addition, it has provided a means to apply analytical review, with minimal staffing, to entire collections of compounds which would otherwise not be possible. The system identifies a manageable subset of the entire compound collection for an analytical specialist, eliminating the need to look at compounds with a high degree of confidence and concentrate on those more likely to be of issue. Simplicity has been the key to its effective and growing use in the organization. The benefits of this system to synthetic chemists are clear—the amount of additional effort on behalf of the chemists’ workflow is negligible but provides a plethora of useful information, including an overall assessment of their compound tentative assignments. With this combination, user acceptance and trust from the medicinal chemistry community was gained. This poster will focus mainly on the addition of an NMR verification filter using commercial NMR software to existing automated in-house HPLC and LC/MS assessment tools.Summary: Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Dissecting the genomic profile of persistently infecting oncolytic Newcastle disease virus (NDVpi) from cancer RNA-Seq data
Ahmad U1, Chan SC2, Chau DM1, Chia SL5, Abdullah S1,3, Yusoff K5 & Veerakumarasivam A1,4*
Appropriateness of MRCP use in a DGH
A Elawad, B Billimoria
Bleeding Pseudoaneurysm in uncommon locations: interesting cases
Dr Joel James (SHO), Dr Chandni Patel (SpR) & Dr Shirish Prabhudesai (Consultant)
Accelerated Ageing in Depression: A Study of Two Cohorts
Mathew A. Harris, Laura de Nooij, Xueyi Shen, Toni-Kim Clarke, Riccardo Marioni, Simon R. Cox, Emma L. Hawkins, Mark J. Adams, Liana Romaniuk, Stephen M. Lawrie, James H. Cole, Andrew M. McIntosh and Heather C. Whalley
Helana Lutfi and Shaban Nuredini