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Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia
EP27435
Poster Title: Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia
Submitted on 14 Apr 2018
Author(s): Mary Laquerre
Affiliations:
This poster was presented at AAAA Conference
Poster Views: 537
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Poster Information
Abstract: Each year millions of children require anesthesia for surgical procedures. At this age the brain is still developing, and constantly undergoing changes including: cerebral plasticity, synapse formation, and remodeling of dendritic spines.
Brain-derived neurotrophic factor is a biomolecule that plays a role in memory, learning and synaptic plasticity. Brain-derived neurotrophic factor stimulates neuron regrowth (neurogenesis), repair, and maturation.
Exposure to anesthesia at a young age can effect the developing brain leading to neurocognitive dysfunction and memory deficiency manifesting in the adult years of life. Impaired brain-derived neurotrophic factor from neonatal exposure to anesthesia causes memory deficiency. Environmental enrichment causes epigenetic manipulation, restoring brain-derived neurotrophic factor expression, leading to improved cognitive function.
Summary: Exposure to anesthesia at a young age can effect the developing brain leading to neurocognitive dysfunction and memory deficiency manifesting in the adult years of life. Impaired brain-derived neurotrophic factor from neonatal exposure to anesthesia causes memory deficiency. Environmental enrichment causes epigenetic manipulation, restoring brain-derived neurotrophic factor expression, leading to improved cognitive function.
References: Wu, J., Bie, B., & Naguib, M. (2016). Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia in Rats. Anesthesiology, 124(3), 624-640. doi:10.1097/aln.0000000000000981
Lynn, Anne. "Faculty of 1000 Evaluation for Delayed Environmental Enrichment Reverses Sevoflurane-induced Memory Impairment in Rats." F1000 - Post-publication Peer Review of the Biomedical Literature, 2012. doi:10.3410/f.13984980.15656056.
Lu, L. X., J. H. Yon, L.B. Carter, and V. Jevtovic-Todorovic. “General Anesthesia Activates BDNF-dependent Neuroapoptosis in the Develoing Rat Brain.” Apoptosis: An International Journal on Programmed Cell Death. September 2006. Accessed April 12, 2019. https://www.ncbi.nlm.nih.gov/pubmed/16738805
Zou, X., F. Liu, X. Zhang, T. A. Patterson, R. Callicott, S. Liu, J. P. Hanig, M. G. Paule, J. R. Slikker, and C. Wang. "Inhalation Anesthetic-induced Neuronal Damage in the Developing Rhesus Monkey." Neurotoxicology
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