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Exploring the Ionization Space in Traditional Electron Ionization with High Resolution GC=TOFMS for a Variety of Compound Classes
EP23009
Poster Title: Exploring the Ionization Space in Traditional Electron Ionization with High Resolution GC=TOFMS for a Variety of Compound Classes
Submitted on 21 May 2015
Author(s): Jonathan D. Byer, David Alonso, Joe Binkley, Charles Lyle, and Jeff Patrick
Affiliations: LECO Corporation
This poster was presented at ASMS 2014
Poster Views: 1,634
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Poster Information
Abstract: Recommended source conditions for contributing electron ionization (EI) mass spectra to commercial libraries are ionization energy of 70 eV and an ion source temperature of 200°C. However, spectral quality is affected by other source parameters, such as filament emission current and differences in instrument manufacturers’ source design.

The primary objective of this study was to optimize LECO’s GC-HRT EI source parameters to enhance the molecular ion of thermally labile compounds like linear alkanes, fatty acid methyl esters, and pesticides.
The secondary objective was to optimize the EI source for other classes of compounds to achieve a global optimum for non-targeted analysis, since this is the primary utility of most time-of-flight mass spectrometry (TOFMS) systems.
Summary: -Source temperature was commonly the most significant variable for maximizing molecular ion peak area.
-Chromatographic peak shape was temperature dependant primarily for the non-volatile compounds.
-Ionization conditions were optimized to maximize molecular ion for a variety of compound classes.
-Ionization conditions do change the peak shape and peak area, which relates directly to library searchability.
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