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Expression Profiling of Circulating Tumor Cells: a Prognostic and Predictive Biomarker in Cancer.
EP22593
Poster Title: Expression Profiling of Circulating Tumor Cells: a Prognostic and Predictive Biomarker in Cancer.
Submitted on 30 Dec 2014
Author(s): Mikael Kubista, Robert Sjöback,Marie Jindrichova, Eva Rohlova, Vendula Novosadová, Siegfrid Hauch, Bahriye Aktas, Mitra Tewes,Maren Bredemeier, and SabineKasimir-Bauer
Affiliations: Bauer4.1TATAA Biocenter, Göteborg, Sweden (www.tataa.com); 2Inst. of Biotechnology, CAS, Czech Republic; 3AdnaGen GmbH, Ostpassage7, D-30853 Langenhagen, Germany (www.adnagen.com); 4Dep of Gynecoland Obstetrics, UniversityHospitalEssen, Germany; 5Depof Med Oncol, West German Cancer Center, University Hospital Essen, Germany.
This poster was presented at Swedish Cancer meeting
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Abstract: We have developed a strategy to predict response to treatment of cancer patients based on expression profiling of circulating tumour cells (CTCs). CTCs are collected from blood using AdnaGen immunomagnetic capture followed by expression profiling with TATAA Biocenter GrandPerformance assays via preamplification. Preliminary results from a pilot study on breast cancer (BC) patients demonstrates excellent sensitivity, technical reproducibility and identifies a set of genes that separates a group of non-responders. The approach shows great promise as liquid biopsy for the motoring of treatments and prediction of responses.
Summary: We show non-responders to treatment among breast cancer patients can be identified by expression profiling of circulating tumor cellsReferences: www.tataa.comReport abuse »
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