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Extracorporeal Shock Wave Therapy in situ – a novel approach to obtain an activated fat graft
Poster Title: Extracorporeal Shock Wave Therapy in situ – a novel approach to obtain an activated fat graft
Submitted on 27 Oct 2017
Author(s): Priglinger Eleni1,2, Peterbauer Anja2,3, Wurzer Christoph1,2,4, Steffenhagen Carolin1,2, Redl Heinz1,2,4, Sandhofer Matthias5, Wolbank Susanne 1,2
Affiliations: 1Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Linz/Vienna 1200, Austria, 2Austrian Cluster for Tissue Regeneration, Vienna 1200, Austria, 3Red Cross Blood Transfusion Service of Upper Austria, Linz 4010, Austria, 4Liporegena GmbH, Breitenfurt 2384, Austria, 5Austrian Academy of Cosmetic Surgery and Aesthetic Medicine, Linz 4020, Austria
This poster was presented at ISSCR Florenz, 2016
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Abstract: One of the mainstays of facial rejuvenation strategies is volume restoration which can be achieved by autologous fat grafting. In our novel approach, we treated the adipose tissue harvest site with extracorporeal shock wave therapy (ESWT) in order to improve the quality of the regenerative cells in situ. The latter was demonstrated by characterizing the cells of the stromal vascular fraction (SVF) in the harvested liposuction material regarding cell yield, ATP content, proliferative capacity, surface marker profile and differentiation potential. While SVF cell yield was only slightly enhanced, viability and ATP concentration of freshly isolated cells as well as proliferation doublings after 3 weeks in culture were significantly increased in the ESWT compared to the untreated group. Likewise, cells expressing mesenchymal and endothelial/pericytic markers were significantly elevated concomitant with an improved differentiation capacity towards the adipogenic lineage. Hence, in situ ESWT might be applied in the future to promote cell fitness and adipogenesis within the fat graft for successful facial rejuvenation strategies with potential long-term graft survival.Summary: Novel approach to improve the quality of the regenerative cells within fat grafts in situ by treating the adipose tissue harvest site with extracorporeal shock wave therapy (ESWT) Report abuse »
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