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Formulation and Characterization of a Nano-particle Drug Delivery System Containing Digoxin and Corticosteroids
EP25613
Poster Title: Formulation and Characterization of a Nano-particle Drug Delivery System Containing Digoxin and Corticosteroids
Submitted on 23 Feb 2017
Author(s): Rudy Smalling, Shrushti Patil, Aditi Pandhare, Amanda Lasher, Shivani Trivedi, Kathleen Halasz, Aum Solanki, Shannon Kelly, Vijaykumar Sutariya.
Affiliations: Department of Pharmaceutical Sciences, USF College of Pharmacy, , University of South Florida, Tampa, Fl, 33612
This poster was presented at USF Health Research Day 2017
Poster Views: 955
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Poster Information
Abstract: Age-related macular degeneration (AMD) is one of the leading causes of blindness in the U.S. Recent studies have found that Triamcinolone Acetonide (TA) suppresses secretion of the inflammatory cytokine, VEGF. Digoxin (DIG), on the other hand, has been reported to suppress hypoxia induced factor (HIF). A combined system with the ability to suppress both VEGF and HIF shows potential in the treatment of AMD. In this study, nanoparticles encapsulating TA were characterized for their size and encapsulation efficiency. These NPs were then placed into a solution of DIG, resulting in a combined drug delivery system (DDS). The in vitro release, cytotoxicity and VEGF inhibition of this DDS were then evaluated. The combination of TA and DIG suppressed VEGF more efficiently than either drug alone. This demonstrates that this DDS could serve as a viable treatment for AMD.Summary: To develop an efficient sustained dual drug delivery system (DDS) of Digoxin (DIG) and corticosteroid Triamcinolone Acetonide (TA) for the suppression of both VEGF and HIF.Report abuse »
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