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Fully Automated LC-MS/MS-based Determination of Bosentanand its Metabolites in Dried Blood Spots using the SCAP™ DBS System
EP20462
Poster Title: Fully Automated LC-MS/MS-based Determination of Bosentanand its Metabolites in Dried Blood Spots using the SCAP™ DBS System
Submitted on 19 Dec 2013
Author(s): Mirko Glinski, Norbert Ganz, Jasper Dingemanse, Laurent Nicolas and Werner Döbelin
Affiliations: Inovalab
Poster Views: 807
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Poster Information
Abstract: The advantages of DBS are:
• Only low amount (25 µL) of test material needed
• Minimal sample processing needed
• Sample storage and shipment at ambient temperature possible.

However automation of the DBS workflow is needed to enable a through put that can compete with conventional plasma analysis. This poster details how the SCAP™ DBS System allows fully-automated DBS analysis via LC-MS/MS without need of time-consuming spot punching and manual extraction.
Summary: Dried Blood Spot (DBS) analysis is a very promising alternative to conventional whole blood and plasma analysis used in drug discovery and development or later in therapeutic drug monitoring with well documented advantages.Report abuse »
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